Circulating Tumor Cells Were Associated with the Number of T Lymphocyte Subsets and NK Cells in Peripheral Blood in Advanced Non-Small-Cell Lung Cancer
Joint Authors
Song, Yong
Zhang, Fang
Lv, Tang-feng
Ye, Liang
Li, Huijuan
Yang, Linfei
Gu, Wei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In this study, we aim to investigate the correlation between circulating tumor cells (CTCs) and the T lymphocyte subsets and NK cells in peripheral blood in non-small-cell lung cancer (NSCLC).
The peripheral blood CTCs were determined by SET-iFISH.
Flow cytometry was used to determine the distribution of T lymphocyte subsets and NK cells.
Forty-one (49%) patients showed positivity for CTCs.
Logistic regression analysis revealed CTC number was negatively correlated with the ratio of CD3+, CD4+, CD4+/CD8+, and NK % in patients at stage IV, while in a positive correlation was noticed between CTC number and regulatory T cell (Tregs) ratio in these patients.
Multivariate analysis was performed in combination with the clinical-pathological materials to identify the risk factors for CTC positivity.
Differentiation, NSCLC stage, percentages of CD3+CD4+ cells, Tregs, and NK cells were the independent risk factors for CTCs.
CTCs were associated with the decrease of immune surveillance in the peripheral blood in NSCLC patients.
The decrease of immune surveillance contributed to the escape of CTCs from the killing effects of the immunocytes, as well as the formation of metastasized lesions in the target organs.
American Psychological Association (APA)
Ye, Liang& Zhang, Fang& Li, Huijuan& Yang, Linfei& Lv, Tang-feng& Gu, Wei…[et al.]. 2017. Circulating Tumor Cells Were Associated with the Number of T Lymphocyte Subsets and NK Cells in Peripheral Blood in Advanced Non-Small-Cell Lung Cancer. Disease Markers،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152391
Modern Language Association (MLA)
Ye, Liang…[et al.]. Circulating Tumor Cells Were Associated with the Number of T Lymphocyte Subsets and NK Cells in Peripheral Blood in Advanced Non-Small-Cell Lung Cancer. Disease Markers No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1152391
American Medical Association (AMA)
Ye, Liang& Zhang, Fang& Li, Huijuan& Yang, Linfei& Lv, Tang-feng& Gu, Wei…[et al.]. Circulating Tumor Cells Were Associated with the Number of T Lymphocyte Subsets and NK Cells in Peripheral Blood in Advanced Non-Small-Cell Lung Cancer. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152391