Role of MMP-1 (-519AG, -1607 1G2G), MMP-3 (Lys45Glu), MMP-7 (-181AG), and MMP-12 (-82AG) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population
المؤلفون المشاركون
Norel, Xavier
Boumiza, Soumaya
Bchir, Sarra
ben Nasr, Hela
Abbassi, Ammar
Jacob, Marie-Paule
Tabka, Zouhair
Chahed, Karim
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-26
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Aims.
The impact of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 Lys45Glu (A/G), MMP-7 -181A/G, and MMP-12 -82A/G variants and plasma MMP levels on obesity and microvascular reactivity in Tunisians.
Methods.
Our population included 202 nonobese and 168 obese subjects.
Anthropometric, biochemical, and microvascular parameters were determined according to standard protocols.
PCR-RFLP and ELISA were used to determine the genetic variants and levels of MMPs, respectively.
Results.
The MMP-3 45Glu (G) allele associates with higher anthropometric values and MMP-3 levels compared to AA genotype carriers (BMI (kg/m2): 30 ± 0.51 versus 27.33 ± 0.8, P=0.004; MMP-3 levels: 7.45 (4.77–11.91) versus 5.21 (3.60–10.21) ng/ml, P=0.006).
The MMP-12 -82G allele was also associated with higher BMI values when compared to subjects carrying the AA genotype (31.41 ± 0.85 versus 28.76 ± 0.43, P<0.001).
Individuals carrying the MMP-3 45G or MMP-12 -82G variants were also associated with a higher risk for severe forms of obesity (MMP-3: OR = 1.9, P=0.002; MMP-12: OR = 2.63, P=0.003).
Similarly, the MMP-7 -181G allele was associated with a higher MMP-7 level and an increased risk for morbid obesity when compared to AA genotype carriers (0.32 (0.31–0.60) versus 0.18 (0.17–0.24) ng/ml, P=0.01; OR = 1.67, P=0.02, resp.).
Conclusion.
MMP-3, MMP-7, and MMP-12 polymorphisms associate with obesity risk and its severity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Boumiza, Soumaya& Bchir, Sarra& ben Nasr, Hela& Abbassi, Ammar& Jacob, Marie-Paule& Norel, Xavier…[et al.]. 2017. Role of MMP-1 (-519AG, -1607 1G2G), MMP-3 (Lys45Glu), MMP-7 (-181AG), and MMP-12 (-82AG) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population. Disease Markers،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1152415
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Boumiza, Soumaya…[et al.]. Role of MMP-1 (-519AG, -1607 1G2G), MMP-3 (Lys45Glu), MMP-7 (-181AG), and MMP-12 (-82AG) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population. Disease Markers No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1152415
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Boumiza, Soumaya& Bchir, Sarra& ben Nasr, Hela& Abbassi, Ammar& Jacob, Marie-Paule& Norel, Xavier…[et al.]. Role of MMP-1 (-519AG, -1607 1G2G), MMP-3 (Lys45Glu), MMP-7 (-181AG), and MMP-12 (-82AG) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1152415
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152415
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر