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Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
المؤلفون المشاركون
Goncalves, Marilda Souza
Adanho, Corynne Stephanie Ahouefa
Santiago, Rayra Pereira
Santana, Sânzio Silva
Pitanga, Thassila Nogueira
Ferreira, Junia Raquel Dutra
Lyra, Isa Menezes
Vieira, Camilo
Guarda, Caroline Conceição
Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Aleluia, Milena Magalhães
Oliveira, Rodrigo Mota
Zanette, Dalila Luciola
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established.
We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children.
Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated.
Hematological, biochemical, immunological, and genetic analyses were performed.
TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin.
We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration.
Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels.
Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s.
The CAR haplotype was associated with higher TAMMV.
In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children.
Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx.
Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santiago, Rayra Pereira& Vieira, Camilo& Adanho, Corynne Stephanie Ahouefa& Santana, Sânzio Silva& Guarda, Caroline Conceição& Figueiredo, Camylla Vilas Boas…[et al.]. 2017. Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease. Disease Markers،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152437
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santiago, Rayra Pereira…[et al.]. Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease. Disease Markers No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1152437
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santiago, Rayra Pereira& Vieira, Camilo& Adanho, Corynne Stephanie Ahouefa& Santana, Sânzio Silva& Guarda, Caroline Conceição& Figueiredo, Camylla Vilas Boas…[et al.]. Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152437
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152437
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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