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Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
Joint Authors
Goncalves, Marilda Souza
Adanho, Corynne Stephanie Ahouefa
Santiago, Rayra Pereira
Santana, Sânzio Silva
Pitanga, Thassila Nogueira
Ferreira, Junia Raquel Dutra
Lyra, Isa Menezes
Vieira, Camilo
Guarda, Caroline Conceição
Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Aleluia, Milena Magalhães
Oliveira, Rodrigo Mota
Zanette, Dalila Luciola
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established.
We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children.
Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated.
Hematological, biochemical, immunological, and genetic analyses were performed.
TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin.
We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration.
Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels.
Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s.
The CAR haplotype was associated with higher TAMMV.
In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children.
Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx.
Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children.
American Psychological Association (APA)
Santiago, Rayra Pereira& Vieira, Camilo& Adanho, Corynne Stephanie Ahouefa& Santana, Sânzio Silva& Guarda, Caroline Conceição& Figueiredo, Camylla Vilas Boas…[et al.]. 2017. Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease. Disease Markers،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152437
Modern Language Association (MLA)
Santiago, Rayra Pereira…[et al.]. Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease. Disease Markers No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1152437
American Medical Association (AMA)
Santiago, Rayra Pereira& Vieira, Camilo& Adanho, Corynne Stephanie Ahouefa& Santana, Sânzio Silva& Guarda, Caroline Conceição& Figueiredo, Camylla Vilas Boas…[et al.]. Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152437