Elevated Serum miR-7, miR-9, miR-122, and miR-141 Are Noninvasive Biomarkers of Acute Pancreatitis
المؤلفون المشاركون
Wang, Cheng
Lu, Pan
Wang, Feng
Wu, Jia
Yan, Jing
Li, Zhuo-ling
Song, Jia-xi
Wang, Jun-jun
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
It has been reported that several microRNAs (miRNAs), such as miR-141, miR-9, and miR-122, are involved in the regulation of pancreatitis-related proteins or that their levels change in acute pancreatitis (AP) animal models.
However, the serum levels, as well as the clinical diagnostic and prognostic values, of these miRNAs in AP patients remain unclear.
Furthermore, as a pancreas- (islet) enriched miRNA, miR-7 was reported to be downregulated in AP patients, which requires further verification.
Methods.
The levels of miR-7, miR-9, miR-122, and miR-141 were examined and compared using qRT-PCR among 80 severe AP patients, 80 mild AP patients, and 74 healthy controls.
Results.
The serum levels of these four miRNAs were increased markedly in the AP patients compared with the controls, and these levels decreased significantly after effective therapy.
Particularly, the level of miR-7 was higher in severe AP patients than in mild AP patients.
ROC curve analysis demonstrated that four miRNAs could be used as potential biomarkers for AP.
Moreover, these miRNAs showed strong positive correlations with CRP, which may be associated with inflammation.
Conclusions.
The serum miR-7, miR-9, miR-122, and miR-141 levels were increased in AP patients.
These 4 miRNAs may represent diagnostic and prognostic biomarkers for AP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Pan& Wang, Feng& Wu, Jia& Wang, Cheng& Yan, Jing& Li, Zhuo-ling…[et al.]. 2017. Elevated Serum miR-7, miR-9, miR-122, and miR-141 Are Noninvasive Biomarkers of Acute Pancreatitis. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152485
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Pan…[et al.]. Elevated Serum miR-7, miR-9, miR-122, and miR-141 Are Noninvasive Biomarkers of Acute Pancreatitis. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152485
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Pan& Wang, Feng& Wu, Jia& Wang, Cheng& Yan, Jing& Li, Zhuo-ling…[et al.]. Elevated Serum miR-7, miR-9, miR-122, and miR-141 Are Noninvasive Biomarkers of Acute Pancreatitis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152485
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152485
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر