Elevated Serum miR-7, miR-9, miR-122, and miR-141 Are Noninvasive Biomarkers of Acute Pancreatitis
Joint Authors
Wang, Cheng
Lu, Pan
Wang, Feng
Wu, Jia
Yan, Jing
Li, Zhuo-ling
Song, Jia-xi
Wang, Jun-jun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
It has been reported that several microRNAs (miRNAs), such as miR-141, miR-9, and miR-122, are involved in the regulation of pancreatitis-related proteins or that their levels change in acute pancreatitis (AP) animal models.
However, the serum levels, as well as the clinical diagnostic and prognostic values, of these miRNAs in AP patients remain unclear.
Furthermore, as a pancreas- (islet) enriched miRNA, miR-7 was reported to be downregulated in AP patients, which requires further verification.
Methods.
The levels of miR-7, miR-9, miR-122, and miR-141 were examined and compared using qRT-PCR among 80 severe AP patients, 80 mild AP patients, and 74 healthy controls.
Results.
The serum levels of these four miRNAs were increased markedly in the AP patients compared with the controls, and these levels decreased significantly after effective therapy.
Particularly, the level of miR-7 was higher in severe AP patients than in mild AP patients.
ROC curve analysis demonstrated that four miRNAs could be used as potential biomarkers for AP.
Moreover, these miRNAs showed strong positive correlations with CRP, which may be associated with inflammation.
Conclusions.
The serum miR-7, miR-9, miR-122, and miR-141 levels were increased in AP patients.
These 4 miRNAs may represent diagnostic and prognostic biomarkers for AP.
American Psychological Association (APA)
Lu, Pan& Wang, Feng& Wu, Jia& Wang, Cheng& Yan, Jing& Li, Zhuo-ling…[et al.]. 2017. Elevated Serum miR-7, miR-9, miR-122, and miR-141 Are Noninvasive Biomarkers of Acute Pancreatitis. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152485
Modern Language Association (MLA)
Lu, Pan…[et al.]. Elevated Serum miR-7, miR-9, miR-122, and miR-141 Are Noninvasive Biomarkers of Acute Pancreatitis. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152485
American Medical Association (AMA)
Lu, Pan& Wang, Feng& Wu, Jia& Wang, Cheng& Yan, Jing& Li, Zhuo-ling…[et al.]. Elevated Serum miR-7, miR-9, miR-122, and miR-141 Are Noninvasive Biomarkers of Acute Pancreatitis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152485