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Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis
المؤلفون المشاركون
Zeng, Xian-Tao
Meng, Xiangyu
Jia, Xiao-Wei
Yuan, Ya-Di
Yao, Zhong-Xiong
Wu, Chang-Jing
Chen, Xiang
Chen, Xue-Hong
Lin, Ying-Mei
Shao, Jun
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Previous studies have revealed that gene polymorphisms of inflammatory factors may influence the development or progression of periodontitis, a main cause of tooth loss in adults; however, due to limitations of individual studies, inconsistent findings were reported.
Objective.
To meta-analytically investigate the relationship between periodontitis and the Interleukin-4 (IL-4) and Interleukin-4 receptor (IL-4R) gene polymorphisms.
Methods.
Databases were searched for relevant case-control studies.
After study selection based on the predefined selection criteria, methodological quality assessment and data extraction were conducted independently by two reviewers, before subsequent statistical analyses.
Results.
37 studies involving 4,385 patients and 5,168 controls were included.
All the studied IL-4 polymorphisms were not significantly associated with periodontitis, except the -33C/T (CT versus CC: OR = 0.50, 95% CI = 0.28–0.88) associated with reduced AgP susceptibility.
Positive association was found between IL-4R Q551 polymorphism and periodontitis susceptibility in three genetic models (R versus Q: OR = 1.59, 95% CI = 1.14–2.22; QR versus QQ: OR = 1.84, 95% CI = 1.21–2.80; RR + QR versus QQ: OR = 1.82, 95% CI = 1.22–2.72).
Conclusions.
A positive association exists between the IL-4R Q551R polymorphism and occurrence of CP.
The IL-4 -33 CT genotype is negatively associated with the occurrence of AgP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jia, Xiao-Wei& Yuan, Ya-Di& Yao, Zhong-Xiong& Wu, Chang-Jing& Chen, Xiang& Chen, Xue-Hong…[et al.]. 2017. Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152511
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jia, Xiao-Wei…[et al.]. Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152511
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jia, Xiao-Wei& Yuan, Ya-Di& Yao, Zhong-Xiong& Wu, Chang-Jing& Chen, Xiang& Chen, Xue-Hong…[et al.]. Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152511
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152511
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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