Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis
Joint Authors
Zeng, Xian-Tao
Meng, Xiangyu
Jia, Xiao-Wei
Yuan, Ya-Di
Yao, Zhong-Xiong
Wu, Chang-Jing
Chen, Xiang
Chen, Xue-Hong
Lin, Ying-Mei
Shao, Jun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Previous studies have revealed that gene polymorphisms of inflammatory factors may influence the development or progression of periodontitis, a main cause of tooth loss in adults; however, due to limitations of individual studies, inconsistent findings were reported.
Objective.
To meta-analytically investigate the relationship between periodontitis and the Interleukin-4 (IL-4) and Interleukin-4 receptor (IL-4R) gene polymorphisms.
Methods.
Databases were searched for relevant case-control studies.
After study selection based on the predefined selection criteria, methodological quality assessment and data extraction were conducted independently by two reviewers, before subsequent statistical analyses.
Results.
37 studies involving 4,385 patients and 5,168 controls were included.
All the studied IL-4 polymorphisms were not significantly associated with periodontitis, except the -33C/T (CT versus CC: OR = 0.50, 95% CI = 0.28–0.88) associated with reduced AgP susceptibility.
Positive association was found between IL-4R Q551 polymorphism and periodontitis susceptibility in three genetic models (R versus Q: OR = 1.59, 95% CI = 1.14–2.22; QR versus QQ: OR = 1.84, 95% CI = 1.21–2.80; RR + QR versus QQ: OR = 1.82, 95% CI = 1.22–2.72).
Conclusions.
A positive association exists between the IL-4R Q551R polymorphism and occurrence of CP.
The IL-4 -33 CT genotype is negatively associated with the occurrence of AgP.
American Psychological Association (APA)
Jia, Xiao-Wei& Yuan, Ya-Di& Yao, Zhong-Xiong& Wu, Chang-Jing& Chen, Xiang& Chen, Xue-Hong…[et al.]. 2017. Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152511
Modern Language Association (MLA)
Jia, Xiao-Wei…[et al.]. Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152511
American Medical Association (AMA)
Jia, Xiao-Wei& Yuan, Ya-Di& Yao, Zhong-Xiong& Wu, Chang-Jing& Chen, Xiang& Chen, Xue-Hong…[et al.]. Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152511