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Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation
المؤلفون المشاركون
Oprea-Ilies, Gabriela
Daley-Brown, Danielle
Vann, Kiara T.
Lanier, Viola
Lee, Regina
Candelaria, Pierre V.
Pattillo, Roland
Gonzalez-Perez, Ruben Rene
Quarshie, Alexander
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-04
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Objective.
The expression of NILCO molecules (Notch, IL-1, and leptin crosstalk outcome) and the association with obesity were investigated in types I and II endometrial cancer (EmCa).
Additionally, the involvement of NILCO in leptin-induced invasiveness of EmCa cells was investigated.
Methods.
The expression of NILCO mRNAs and proteins were analyzed in EmCa from African-American n=29 and Chinese patients (tissue array, n=120 cases).
The role of NILCO in leptin-induced invasion of Ishikawa and An3ca EmCa cells was investigated using Notch, IL-1, and leptin signaling inhibitors.
Results.
NILCO molecules were expressed higher in type II EmCa, regardless of ethnic background or obesity status of patients.
NILCO proteins were mainly localized in the cellular membrane and cytoplasm of type II EmCa.
Additionally, EmCa from obese African-American patients showed higher levels of NILCO molecules than EmCa from lean patients.
Notably, leptin-induced EmCa cell invasion was abrogated by NILCO inhibitors.
Conclusion.
Type II EmCa expressed higher NILCO molecules, which may suggest it is involved in the progression of the more aggressive EmCa phenotype.
Obesity was associated with higher expression of NILCO molecules in EmCa.
Leptin-induced cell invasion was dependent on NILCO.
Hence, NILCO might be involved in tumor progression and could represent a new target/biomarker for type II EmCa.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Daley-Brown, Danielle& Oprea-Ilies, Gabriela& Vann, Kiara T.& Lanier, Viola& Lee, Regina& Candelaria, Pierre V.…[et al.]. 2017. Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation. Disease Markers،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1152532
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Daley-Brown, Danielle…[et al.]. Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation. Disease Markers No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1152532
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Daley-Brown, Danielle& Oprea-Ilies, Gabriela& Vann, Kiara T.& Lanier, Viola& Lee, Regina& Candelaria, Pierre V.…[et al.]. Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1152532
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152532
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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