Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation
Joint Authors
Oprea-Ilies, Gabriela
Daley-Brown, Danielle
Vann, Kiara T.
Lanier, Viola
Lee, Regina
Candelaria, Pierre V.
Pattillo, Roland
Gonzalez-Perez, Ruben Rene
Quarshie, Alexander
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objective.
The expression of NILCO molecules (Notch, IL-1, and leptin crosstalk outcome) and the association with obesity were investigated in types I and II endometrial cancer (EmCa).
Additionally, the involvement of NILCO in leptin-induced invasiveness of EmCa cells was investigated.
Methods.
The expression of NILCO mRNAs and proteins were analyzed in EmCa from African-American n=29 and Chinese patients (tissue array, n=120 cases).
The role of NILCO in leptin-induced invasion of Ishikawa and An3ca EmCa cells was investigated using Notch, IL-1, and leptin signaling inhibitors.
Results.
NILCO molecules were expressed higher in type II EmCa, regardless of ethnic background or obesity status of patients.
NILCO proteins were mainly localized in the cellular membrane and cytoplasm of type II EmCa.
Additionally, EmCa from obese African-American patients showed higher levels of NILCO molecules than EmCa from lean patients.
Notably, leptin-induced EmCa cell invasion was abrogated by NILCO inhibitors.
Conclusion.
Type II EmCa expressed higher NILCO molecules, which may suggest it is involved in the progression of the more aggressive EmCa phenotype.
Obesity was associated with higher expression of NILCO molecules in EmCa.
Leptin-induced cell invasion was dependent on NILCO.
Hence, NILCO might be involved in tumor progression and could represent a new target/biomarker for type II EmCa.
American Psychological Association (APA)
Daley-Brown, Danielle& Oprea-Ilies, Gabriela& Vann, Kiara T.& Lanier, Viola& Lee, Regina& Candelaria, Pierre V.…[et al.]. 2017. Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation. Disease Markers،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1152532
Modern Language Association (MLA)
Daley-Brown, Danielle…[et al.]. Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation. Disease Markers No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1152532
American Medical Association (AMA)
Daley-Brown, Danielle& Oprea-Ilies, Gabriela& Vann, Kiara T.& Lanier, Viola& Lee, Regina& Candelaria, Pierre V.…[et al.]. Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1152532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152532