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Allium stipitatum Extract Exhibits In Vivo Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus and Accelerates Burn Wound Healing in a Full-Thickness Murine Burn Model
المؤلفون المشاركون
Nathan, Jayakayatri Jeevajothi
van Belkum, Alex
Abba, Yusuf
Neela, Vasantha Kumari
Karunanidhi, Arunkumar
Ghaznavi-Rad, Ehsanollah
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-22
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The in vivo antibacterial and burn wound healing potency of Persian shallot bulbs (Allium stipitatum) were explored in a mice burn model infected with methicillin-resistant Staphylococcus aureus (MRSA).
Hexane (ASHE) and dichloromethane (ASDE) extracts were tested.
Female BALB/c mice were inflicted with third-degree thermal injury followed by infection with MRSA.
ASHE and ASDE formulated with simple ointment base (SOB) at concentrations of 1%, 2%, and 5% (w/w) were topically applied to burn wounds twice a day for 20 days.
Silver sulfadiazine (1%) served as drug positive control.
Microbiological analysis was carried out on 1, 2, 3, 4, and 5 days postwounding (dpw) and histopathological analysis at the end of the experiment (20 dpw).
Both ointments demonstrated strong antibacterial activity with complete elimination of MRSA at 48–72 h after infection.
The rate of wound contraction was higher (95–100%) in mice groups treated with ASHE and ASDE ointments after 15 dpw.
Histological analysis revealed significant increase ( p < 0.05 ) in epithelialization and collagenation in treated groups.
The ASHE and ASDE were found to be relatively noncytotoxic and safe to Vero cell line (383.4 μg mL−1; 390.6 μg mL−1), suggesting the extracts as safe topical antibacterial as well as promising alternatives in managing thermal injuries.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karunanidhi, Arunkumar& Ghaznavi-Rad, Ehsanollah& Nathan, Jayakayatri Jeevajothi& Abba, Yusuf& van Belkum, Alex& Neela, Vasantha Kumari. 2017. Allium stipitatum Extract Exhibits In Vivo Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus and Accelerates Burn Wound Healing in a Full-Thickness Murine Burn Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153141
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Karunanidhi, Arunkumar…[et al.]. Allium stipitatum Extract Exhibits In Vivo Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus and Accelerates Burn Wound Healing in a Full-Thickness Murine Burn Model. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1153141
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karunanidhi, Arunkumar& Ghaznavi-Rad, Ehsanollah& Nathan, Jayakayatri Jeevajothi& Abba, Yusuf& van Belkum, Alex& Neela, Vasantha Kumari. Allium stipitatum Extract Exhibits In Vivo Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus and Accelerates Burn Wound Healing in a Full-Thickness Murine Burn Model. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153141
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153141
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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