Antiarthritic Activity of Qi-Wu Rheumatism Granule (a Chinese Herbal Compound) on Complete Freund’s Adjuvant-Induced Arthritis in Rats
المؤلفون المشاركون
Xu, Qi
Zhou, Yong
Zhang, Rong
Sun, Zhan
Cheng, Lu-feng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Objective.
The aim was to study the therapeutic effects and mechanisms of QWRG on adjuvant-induced RA in rats.
Methods.
The RA rat models were manipulated and subsequently divided into five experimental groups: AIA, DEX, and QWRG groups.
The paw volume, body weight, arthritic score, and mechanical nociceptive threshold were assessed.
The serum levels of the RF, MDA, ALP, AST, ALT, IL-1β, IL-2, IL-16, and TNF-α were measured.
The proliferative capacity of lymphocytes was evaluated, and the synovial tissue was histopathologically examined.
Results.
The paw swelling and arthritic scores were relieved, and the variation of relative body weight and mechanical nociceptive threshold had improved in the AIA rats.
The serum levels of RF, MDA, ALP, AST, and ALT were alleviated, and the inflammation and cartilage damage were effectively attenuated in the AIA rats.
Simultaneously, the inflammation of the synovial cavity was alleviated, and the grading of synovitis reduced by inhibiting the expressions of IL-1β, TNF-α, and IL-16 in the serum and synovium tissue.
Conclusion.
Our results suggested that the antiarthritic properties of QWRG may be due to immunodepression and downregulation of inflammatory cytokines, which may be a potential candidate for the treatment of RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Qi& Zhou, Yong& Zhang, Rong& Sun, Zhan& Cheng, Lu-feng. 2017. Antiarthritic Activity of Qi-Wu Rheumatism Granule (a Chinese Herbal Compound) on Complete Freund’s Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153167
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Qi…[et al.]. Antiarthritic Activity of Qi-Wu Rheumatism Granule (a Chinese Herbal Compound) on Complete Freund’s Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1153167
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Qi& Zhou, Yong& Zhang, Rong& Sun, Zhan& Cheng, Lu-feng. Antiarthritic Activity of Qi-Wu Rheumatism Granule (a Chinese Herbal Compound) on Complete Freund’s Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153167
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153167
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر