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Antiarthritic Activity of Qi-Wu Rheumatism Granule (a Chinese Herbal Compound) on Complete Freund’s Adjuvant-Induced Arthritis in Rats
Joint Authors
Xu, Qi
Zhou, Yong
Zhang, Rong
Sun, Zhan
Cheng, Lu-feng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
The aim was to study the therapeutic effects and mechanisms of QWRG on adjuvant-induced RA in rats.
Methods.
The RA rat models were manipulated and subsequently divided into five experimental groups: AIA, DEX, and QWRG groups.
The paw volume, body weight, arthritic score, and mechanical nociceptive threshold were assessed.
The serum levels of the RF, MDA, ALP, AST, ALT, IL-1β, IL-2, IL-16, and TNF-α were measured.
The proliferative capacity of lymphocytes was evaluated, and the synovial tissue was histopathologically examined.
Results.
The paw swelling and arthritic scores were relieved, and the variation of relative body weight and mechanical nociceptive threshold had improved in the AIA rats.
The serum levels of RF, MDA, ALP, AST, and ALT were alleviated, and the inflammation and cartilage damage were effectively attenuated in the AIA rats.
Simultaneously, the inflammation of the synovial cavity was alleviated, and the grading of synovitis reduced by inhibiting the expressions of IL-1β, TNF-α, and IL-16 in the serum and synovium tissue.
Conclusion.
Our results suggested that the antiarthritic properties of QWRG may be due to immunodepression and downregulation of inflammatory cytokines, which may be a potential candidate for the treatment of RA.
American Psychological Association (APA)
Xu, Qi& Zhou, Yong& Zhang, Rong& Sun, Zhan& Cheng, Lu-feng. 2017. Antiarthritic Activity of Qi-Wu Rheumatism Granule (a Chinese Herbal Compound) on Complete Freund’s Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153167
Modern Language Association (MLA)
Xu, Qi…[et al.]. Antiarthritic Activity of Qi-Wu Rheumatism Granule (a Chinese Herbal Compound) on Complete Freund’s Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1153167
American Medical Association (AMA)
Xu, Qi& Zhou, Yong& Zhang, Rong& Sun, Zhan& Cheng, Lu-feng. Antiarthritic Activity of Qi-Wu Rheumatism Granule (a Chinese Herbal Compound) on Complete Freund’s Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153167