Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method
المؤلفون المشاركون
Ma, Zengchun
Xiao, Chengrong
Tan, Hongling
Gao, Yue
Wang, Yuguang
Xu, Huanhua
Hao, Fei-Ran
Wang, Mei-Xi
Ren, Si-Jia
Li, Ming
Tang, Xiang-Lin
Liang, Qian-De
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The purpose of this work was to study the influences of Realgar-Indigo naturalis (RIF) and its principal element realgar on 4 main cytochrome P450 enzymes activities in rats.
A simple and efficient cocktail method was developed to detect the four probe drugs simultaneously.
In this study, Wistar rats were administered intragastric RIF and realgar for 14 days; mixed probe drugs were injected into rats by caudal vein.
Through analyzing the pharmacokinetic parameter of mixed probe drugs in rats, we can calculate the CYPs activities.
The results showed that RIF could inhibit CYP1A2 enzyme activity and induce CYP2C11 enzyme activity significantly.
Interestingly, in realgar high dosage group, CYP3A1/2 enzyme activity was inhibited significantly, and different dosage of realgar manifested a good dose-dependent manner.
The RIF results indicated that drug coadministrated with RIF may need to be paid attention in relation to drug-drug interactions (DDIs).
Realgar, a toxic traditional Chinese medicine (TCM), does have curative effect on acute promyelocytic leukemia (APL).
Its toxicity studies should be focused on.
We found that, in realgar high dosage group, CYP3A1/2 enzymes activity was inhibited.
This phenomenon may explain its potential toxicity mechanism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Huanhua& Hao, Fei-Ran& Wang, Mei-Xi& Ren, Si-Jia& Li, Ming& Tan, Hongling…[et al.]. 2017. Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153241
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Huanhua…[et al.]. Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153241
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Huanhua& Hao, Fei-Ran& Wang, Mei-Xi& Ren, Si-Jia& Li, Ming& Tan, Hongling…[et al.]. Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153241
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153241
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر