Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method
Joint Authors
Ma, Zengchun
Xiao, Chengrong
Tan, Hongling
Gao, Yue
Wang, Yuguang
Xu, Huanhua
Hao, Fei-Ran
Wang, Mei-Xi
Ren, Si-Jia
Li, Ming
Tang, Xiang-Lin
Liang, Qian-De
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The purpose of this work was to study the influences of Realgar-Indigo naturalis (RIF) and its principal element realgar on 4 main cytochrome P450 enzymes activities in rats.
A simple and efficient cocktail method was developed to detect the four probe drugs simultaneously.
In this study, Wistar rats were administered intragastric RIF and realgar for 14 days; mixed probe drugs were injected into rats by caudal vein.
Through analyzing the pharmacokinetic parameter of mixed probe drugs in rats, we can calculate the CYPs activities.
The results showed that RIF could inhibit CYP1A2 enzyme activity and induce CYP2C11 enzyme activity significantly.
Interestingly, in realgar high dosage group, CYP3A1/2 enzyme activity was inhibited significantly, and different dosage of realgar manifested a good dose-dependent manner.
The RIF results indicated that drug coadministrated with RIF may need to be paid attention in relation to drug-drug interactions (DDIs).
Realgar, a toxic traditional Chinese medicine (TCM), does have curative effect on acute promyelocytic leukemia (APL).
Its toxicity studies should be focused on.
We found that, in realgar high dosage group, CYP3A1/2 enzymes activity was inhibited.
This phenomenon may explain its potential toxicity mechanism.
American Psychological Association (APA)
Xu, Huanhua& Hao, Fei-Ran& Wang, Mei-Xi& Ren, Si-Jia& Li, Ming& Tan, Hongling…[et al.]. 2017. Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153241
Modern Language Association (MLA)
Xu, Huanhua…[et al.]. Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153241
American Medical Association (AMA)
Xu, Huanhua& Hao, Fei-Ran& Wang, Mei-Xi& Ren, Si-Jia& Li, Ming& Tan, Hongling…[et al.]. Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153241