Kidney-Replenishing Herb Induces SOCS-3 Expression via ERKMAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells
المؤلفون المشاركون
Xing, Chang-ying
Zhang, De-xiang
Gui, Sui-qi
Tao, Min-fang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Kidney-replenishing herb is a traditional medicine formula in China which has been widely used for clinical treatment of recurrent miscarriage.
Our previous study showed that Kidney-replenishing herb could promote proliferation and inhibit apoptosis of the human first-trimester trophoblasts.
In the present study, we further explored the potential mechanism and signal pathway of Kidney-replenishing herb on human trophoblast cells.
Our research showed that Kidney-replenishing herb stimulated proliferation and reduced apoptosis of human trophoblast cells in vitro, and this appeared to be positive correlation with SOCS-3 transcription, suggesting that Kidney-replenishing herb regulated biological functions of human trophoblast cells by inducing SCOS-3 expression.
Furthermore, the Kidney-replenishing herb treatment stimulated the phosphorylation of ERK1/2, and blocking the signaling pathway by mitogen-activated protein MAPK (MEK) inhibitor, U0126, inhibited Kidney-replenishing herb-induced SOCS-3 transcription, depressed proliferation, and promoted apoptosis of human trophoblasts.
Kidney-replenishing herbs still induced ERK1/2 phosphorylation after SOCS-3 siRNA silence.
Overexpression of SOCS-3 stimulated the proliferation of trophoblast.
These findings suggest that SOCS-3 expression is induced by Kidney-replenishing herbs via activation of MAPK pathways, and this may possibly be involved in promoting human trophoblast cells growth which is contributed to embryo development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xing, Chang-ying& Zhang, De-xiang& Gui, Sui-qi& Tao, Min-fang. 2017. Kidney-Replenishing Herb Induces SOCS-3 Expression via ERKMAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153253
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xing, Chang-ying…[et al.]. Kidney-Replenishing Herb Induces SOCS-3 Expression via ERKMAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1153253
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xing, Chang-ying& Zhang, De-xiang& Gui, Sui-qi& Tao, Min-fang. Kidney-Replenishing Herb Induces SOCS-3 Expression via ERKMAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153253
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153253
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر