Kidney-Replenishing Herb Induces SOCS-3 Expression via ERKMAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells
Joint Authors
Xing, Chang-ying
Zhang, De-xiang
Gui, Sui-qi
Tao, Min-fang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Kidney-replenishing herb is a traditional medicine formula in China which has been widely used for clinical treatment of recurrent miscarriage.
Our previous study showed that Kidney-replenishing herb could promote proliferation and inhibit apoptosis of the human first-trimester trophoblasts.
In the present study, we further explored the potential mechanism and signal pathway of Kidney-replenishing herb on human trophoblast cells.
Our research showed that Kidney-replenishing herb stimulated proliferation and reduced apoptosis of human trophoblast cells in vitro, and this appeared to be positive correlation with SOCS-3 transcription, suggesting that Kidney-replenishing herb regulated biological functions of human trophoblast cells by inducing SCOS-3 expression.
Furthermore, the Kidney-replenishing herb treatment stimulated the phosphorylation of ERK1/2, and blocking the signaling pathway by mitogen-activated protein MAPK (MEK) inhibitor, U0126, inhibited Kidney-replenishing herb-induced SOCS-3 transcription, depressed proliferation, and promoted apoptosis of human trophoblasts.
Kidney-replenishing herbs still induced ERK1/2 phosphorylation after SOCS-3 siRNA silence.
Overexpression of SOCS-3 stimulated the proliferation of trophoblast.
These findings suggest that SOCS-3 expression is induced by Kidney-replenishing herbs via activation of MAPK pathways, and this may possibly be involved in promoting human trophoblast cells growth which is contributed to embryo development.
American Psychological Association (APA)
Xing, Chang-ying& Zhang, De-xiang& Gui, Sui-qi& Tao, Min-fang. 2017. Kidney-Replenishing Herb Induces SOCS-3 Expression via ERKMAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153253
Modern Language Association (MLA)
Xing, Chang-ying…[et al.]. Kidney-Replenishing Herb Induces SOCS-3 Expression via ERKMAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1153253
American Medical Association (AMA)
Xing, Chang-ying& Zhang, De-xiang& Gui, Sui-qi& Tao, Min-fang. Kidney-Replenishing Herb Induces SOCS-3 Expression via ERKMAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153253