Cytochrome P450 and P-Glycoprotein-Mediated Interactions Involving African Herbs Indicated for Common Noncommunicable Diseases
المؤلفون المشاركون
Ondieki, Gregory
Nyagblordzro, Makafui
Kikete, Siambi
Liang, Rongjia
Wang, Lili
He, Xin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-31
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Herbal remedies are regularly used to complement conventional therapies in the treatment of various illnesses in Africa.
This may be because they are relatively cheap and easily accessible and are believed by many to be safe, cause fewer side effects, and are less likely to cause dependency.
On the contrary, many herbs have been shown to alter the pharmacokinetics of coadministered allopathic medicines and can either synergize or antagonize therapeutic effects as well as altering the toxicity profiles of these drugs.
Current disease burden data point towards epidemiological transitions characterised by increasing urbanization and changing lifestyles, risk factors for chronic diseases like hypertension, diabetes, and cancer which often present as multimorbidities.
As a result, we highlight African herb-drug interactions (HDIs) modulated via cytochrome P450 enzyme family (CYP) and P-glycoprotein (P-gp) and the consequences thereof in relation to antihypertensive, antidiabetic, and anticancer drugs.
CYPs are enzymes which account for to up to 70% of drug metabolism while P-gp is an efflux pump that extrudes drug substrates out of cells.
Consequently, regulation of the relative activity of both CYP and P-gp by African herbs influences the effective drug concentration at the site of action and modifies therapeutic outcomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ondieki, Gregory& Nyagblordzro, Makafui& Kikete, Siambi& Liang, Rongjia& Wang, Lili& He, Xin. 2017. Cytochrome P450 and P-Glycoprotein-Mediated Interactions Involving African Herbs Indicated for Common Noncommunicable Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1153287
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ondieki, Gregory…[et al.]. Cytochrome P450 and P-Glycoprotein-Mediated Interactions Involving African Herbs Indicated for Common Noncommunicable Diseases. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1153287
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ondieki, Gregory& Nyagblordzro, Makafui& Kikete, Siambi& Liang, Rongjia& Wang, Lili& He, Xin. Cytochrome P450 and P-Glycoprotein-Mediated Interactions Involving African Herbs Indicated for Common Noncommunicable Diseases. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1153287
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153287
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر