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Cytochrome P450 and P-Glycoprotein-Mediated Interactions Involving African Herbs Indicated for Common Noncommunicable Diseases
Joint Authors
Ondieki, Gregory
Nyagblordzro, Makafui
Kikete, Siambi
Liang, Rongjia
Wang, Lili
He, Xin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Herbal remedies are regularly used to complement conventional therapies in the treatment of various illnesses in Africa.
This may be because they are relatively cheap and easily accessible and are believed by many to be safe, cause fewer side effects, and are less likely to cause dependency.
On the contrary, many herbs have been shown to alter the pharmacokinetics of coadministered allopathic medicines and can either synergize or antagonize therapeutic effects as well as altering the toxicity profiles of these drugs.
Current disease burden data point towards epidemiological transitions characterised by increasing urbanization and changing lifestyles, risk factors for chronic diseases like hypertension, diabetes, and cancer which often present as multimorbidities.
As a result, we highlight African herb-drug interactions (HDIs) modulated via cytochrome P450 enzyme family (CYP) and P-glycoprotein (P-gp) and the consequences thereof in relation to antihypertensive, antidiabetic, and anticancer drugs.
CYPs are enzymes which account for to up to 70% of drug metabolism while P-gp is an efflux pump that extrudes drug substrates out of cells.
Consequently, regulation of the relative activity of both CYP and P-gp by African herbs influences the effective drug concentration at the site of action and modifies therapeutic outcomes.
American Psychological Association (APA)
Ondieki, Gregory& Nyagblordzro, Makafui& Kikete, Siambi& Liang, Rongjia& Wang, Lili& He, Xin. 2017. Cytochrome P450 and P-Glycoprotein-Mediated Interactions Involving African Herbs Indicated for Common Noncommunicable Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1153287
Modern Language Association (MLA)
Ondieki, Gregory…[et al.]. Cytochrome P450 and P-Glycoprotein-Mediated Interactions Involving African Herbs Indicated for Common Noncommunicable Diseases. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1153287
American Medical Association (AMA)
Ondieki, Gregory& Nyagblordzro, Makafui& Kikete, Siambi& Liang, Rongjia& Wang, Lili& He, Xin. Cytochrome P450 and P-Glycoprotein-Mediated Interactions Involving African Herbs Indicated for Common Noncommunicable Diseases. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1153287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153287