Indoxyl Sulfate Elimination in Renal Replacement Therapy: Influence of Citrate- versus Acetate-Buffering Component during Bicarbonate Dialysis
المؤلفون المشاركون
Dusilova-Sulkova, Sylvie
Safranek, Roman
Hyšpler, Radomír
Tichá, Alena
Zadák, Zdeněk
Moučka, Petr
Nývltová, Zora
Štochlová, Karolína
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Indoxyl sulfate has been identified as a major factor in the dysregulation of several genes.
It is classified as a poorly dialyzable uremic toxin and thus a leading cause in the poor survival rate of dialysis patients.
A monocentric, prospective, open cohort study was performed in 43 male patients undergoing chronic renal replacement therapy in a single hemodialysis center.
The aim of the study was to determine the influence of acetate- versus citrate-buffered dialysis fluids in hemodialysis (HD) and postdilution hemodiafiltration (HDF) settings on the elimination of indoxyl sulfate.
Also, additional factors potentially influencing the serum concentration of indoxyl sulfate were evaluated.
For this purpose, the predialysis and postdialysis concentration ratio of indoxyl sulfate and total protein was determined.
The difference was of 1.15 (0.61; 2.10), 0.89 (0.53; 1.66), 0.32 (0.07; 0.63), and 0.44 (0.27; 0.77) μmol/g in acetate HD and HDF and citrate HD and HDF, respectively.
Acetate HD and HDF were superior when concerning IS elimination when compared to citrate HD and HDF.
Moreover, residual diuresis was determined as the only predictor of lower indoxyl sulfate concentration, suggesting that it should be preserved as long as possible.
This trial is registered with EU PAS Register of Studies EUPAS23714.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hyšpler, Radomír& Tichá, Alena& Safranek, Roman& Moučka, Petr& Nývltová, Zora& Štochlová, Karolína…[et al.]. 2018. Indoxyl Sulfate Elimination in Renal Replacement Therapy: Influence of Citrate- versus Acetate-Buffering Component during Bicarbonate Dialysis. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153295
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hyšpler, Radomír…[et al.]. Indoxyl Sulfate Elimination in Renal Replacement Therapy: Influence of Citrate- versus Acetate-Buffering Component during Bicarbonate Dialysis. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153295
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hyšpler, Radomír& Tichá, Alena& Safranek, Roman& Moučka, Petr& Nývltová, Zora& Štochlová, Karolína…[et al.]. Indoxyl Sulfate Elimination in Renal Replacement Therapy: Influence of Citrate- versus Acetate-Buffering Component during Bicarbonate Dialysis. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153295
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153295
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر