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Indoxyl Sulfate Elimination in Renal Replacement Therapy: Influence of Citrate- versus Acetate-Buffering Component during Bicarbonate Dialysis
Joint Authors
Dusilova-Sulkova, Sylvie
Safranek, Roman
Hyšpler, Radomír
Tichá, Alena
Zadák, Zdeněk
Moučka, Petr
Nývltová, Zora
Štochlová, Karolína
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Indoxyl sulfate has been identified as a major factor in the dysregulation of several genes.
It is classified as a poorly dialyzable uremic toxin and thus a leading cause in the poor survival rate of dialysis patients.
A monocentric, prospective, open cohort study was performed in 43 male patients undergoing chronic renal replacement therapy in a single hemodialysis center.
The aim of the study was to determine the influence of acetate- versus citrate-buffered dialysis fluids in hemodialysis (HD) and postdilution hemodiafiltration (HDF) settings on the elimination of indoxyl sulfate.
Also, additional factors potentially influencing the serum concentration of indoxyl sulfate were evaluated.
For this purpose, the predialysis and postdialysis concentration ratio of indoxyl sulfate and total protein was determined.
The difference was of 1.15 (0.61; 2.10), 0.89 (0.53; 1.66), 0.32 (0.07; 0.63), and 0.44 (0.27; 0.77) μmol/g in acetate HD and HDF and citrate HD and HDF, respectively.
Acetate HD and HDF were superior when concerning IS elimination when compared to citrate HD and HDF.
Moreover, residual diuresis was determined as the only predictor of lower indoxyl sulfate concentration, suggesting that it should be preserved as long as possible.
This trial is registered with EU PAS Register of Studies EUPAS23714.
American Psychological Association (APA)
Hyšpler, Radomír& Tichá, Alena& Safranek, Roman& Moučka, Petr& Nývltová, Zora& Štochlová, Karolína…[et al.]. 2018. Indoxyl Sulfate Elimination in Renal Replacement Therapy: Influence of Citrate- versus Acetate-Buffering Component during Bicarbonate Dialysis. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153295
Modern Language Association (MLA)
Hyšpler, Radomír…[et al.]. Indoxyl Sulfate Elimination in Renal Replacement Therapy: Influence of Citrate- versus Acetate-Buffering Component during Bicarbonate Dialysis. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153295
American Medical Association (AMA)
Hyšpler, Radomír& Tichá, Alena& Safranek, Roman& Moučka, Petr& Nývltová, Zora& Štochlová, Karolína…[et al.]. Indoxyl Sulfate Elimination in Renal Replacement Therapy: Influence of Citrate- versus Acetate-Buffering Component during Bicarbonate Dialysis. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153295