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Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment
المؤلفون المشاركون
Huang, Chih-Yang
Lin, Hung-Jen
Chang, Hen-Hong
Chang, Yung-Ming
Tsai, Chuan-Te
Chang, Hsin-Nung
Lin, Shu-Luan
PadmaViswanadha, Vijaya
Chen, Ray-Jade
Tsai, Chin-Chuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-05
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Aging is a complex physiological phenomenon accelerated by ROS accumulation, with multisystem decline and increasing vulnerability to degenerative diseases and death.
Cardiac hypertrophy is a key pathophysiological component that accompanies the aging process.
Alpinate Oxyphyllae Fructus (Alpinia oxyphylla MIQ, AOF) is a traditional Chinese medicine, which provides cardioprotective activity against aging, hypertension, and cerebrovascular disorders.
In this study, we found the protective effect of AOF against cardiac hypertrophy in D-galactose-induced aging rat model.
The results showed that treating rats with D-galactose resulted in pathological hypertrophy as evident from the morphology change, increased left ventricular weight/whole heart weight, and expression of hypertrophy-related markers (MYH7 and BNP).
Both concentric and eccentric cardiac hypertrophy signaling proteins were upregulated in aging rat model.
However, these pathological changes were significantly improved in AOF treated group (AM and AH) in a dose-dependent manner.
AOF negatively modulated D-galactose-induced cardiac hypertrophy signaling mechanism to attenuate ventricular hypertrophy.
These enhanced cardioprotective activities following oral administration of AOF reflect the potential use of AOF for antiaging treatments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Yung-Ming& Chang, Hen-Hong& Lin, Hung-Jen& Tsai, Chin-Chuan& Tsai, Chuan-Te& Chang, Hsin-Nung…[et al.]. 2017. Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Yung-Ming…[et al.]. Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1153296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Yung-Ming& Chang, Hen-Hong& Lin, Hung-Jen& Tsai, Chin-Chuan& Tsai, Chuan-Te& Chang, Hsin-Nung…[et al.]. Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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