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Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment
Joint Authors
Huang, Chih-Yang
Lin, Hung-Jen
Chang, Hen-Hong
Chang, Yung-Ming
Tsai, Chuan-Te
Chang, Hsin-Nung
Lin, Shu-Luan
PadmaViswanadha, Vijaya
Chen, Ray-Jade
Tsai, Chin-Chuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Aging is a complex physiological phenomenon accelerated by ROS accumulation, with multisystem decline and increasing vulnerability to degenerative diseases and death.
Cardiac hypertrophy is a key pathophysiological component that accompanies the aging process.
Alpinate Oxyphyllae Fructus (Alpinia oxyphylla MIQ, AOF) is a traditional Chinese medicine, which provides cardioprotective activity against aging, hypertension, and cerebrovascular disorders.
In this study, we found the protective effect of AOF against cardiac hypertrophy in D-galactose-induced aging rat model.
The results showed that treating rats with D-galactose resulted in pathological hypertrophy as evident from the morphology change, increased left ventricular weight/whole heart weight, and expression of hypertrophy-related markers (MYH7 and BNP).
Both concentric and eccentric cardiac hypertrophy signaling proteins were upregulated in aging rat model.
However, these pathological changes were significantly improved in AOF treated group (AM and AH) in a dose-dependent manner.
AOF negatively modulated D-galactose-induced cardiac hypertrophy signaling mechanism to attenuate ventricular hypertrophy.
These enhanced cardioprotective activities following oral administration of AOF reflect the potential use of AOF for antiaging treatments.
American Psychological Association (APA)
Chang, Yung-Ming& Chang, Hen-Hong& Lin, Hung-Jen& Tsai, Chin-Chuan& Tsai, Chuan-Te& Chang, Hsin-Nung…[et al.]. 2017. Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153296
Modern Language Association (MLA)
Chang, Yung-Ming…[et al.]. Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1153296
American Medical Association (AMA)
Chang, Yung-Ming& Chang, Hen-Hong& Lin, Hung-Jen& Tsai, Chin-Chuan& Tsai, Chuan-Te& Chang, Hsin-Nung…[et al.]. Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153296