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Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats
المؤلفون المشاركون
Aminul Islam, Md.
Khalil, Md. Ibrahim
Alam, Nadia
Hossain, M. Sabir
Saha, Moumoni
Rumpa, Nur-E-Noushin
Hossen, Md. Sakib
Ali, Md. Yousuf
Tanvir, E. M.
Bhoumik, Nikhil Chandra
Paul, Sudip
Gan, Siew Hua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-19
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The antihyperglycemic, antidiabetic, and antioxidant potentials of the methanolic extract of Garcinia pedunculata (GP) fruit in rats were investigated.
The acute antihyperglycemic effect of different doses of GP was studied in normal male Wistar rats.
Diabetes was induced by streptozotocin (STZ) injection in another cohort of male Wistar rats and they showed significantly higher blood glucose and glycated hemoglobin (HbA1c) levels, altered lipid profiles, and lower insulin levels compared to nondiabetic control animals.
There were increased lipid peroxidation and reduced levels of cellular antioxidant enzymes in different tissues of diabetic rats.
However, oral administration of GP extracts, especially the highest dose (1000 mg/kg), significantly ameliorated hyperglycemia (42%); elevated insulin levels (165%); decreased HbA1c (29.4%); restored lipid levels (reduction in TG by 25%, TC by 15%, and LDL-C by 75% and increase in HDL-C by 4%), liver and renal function markers, and lipid peroxidation (reduction by 52% in the liver, 39% in the kidney, 44% in the heart, and 46% in the pancreas); and stimulated tissue antioxidant enzymes to near normalcy.
Overall, the findings suggest that GP fruit is effective against hyperglycemia and could be used in the treatment of diabetes and its complications and other oxidative stress-mediated pathological conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Md. Yousuf& Paul, Sudip& Tanvir, E. M.& Hossen, Md. Sakib& Rumpa, Nur-E-Noushin& Saha, Moumoni…[et al.]. 2017. Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1153400
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Md. Yousuf…[et al.]. Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1153400
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Md. Yousuf& Paul, Sudip& Tanvir, E. M.& Hossen, Md. Sakib& Rumpa, Nur-E-Noushin& Saha, Moumoni…[et al.]. Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1153400
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153400
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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