Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats
Joint Authors
Aminul Islam, Md.
Khalil, Md. Ibrahim
Alam, Nadia
Hossain, M. Sabir
Saha, Moumoni
Rumpa, Nur-E-Noushin
Hossen, Md. Sakib
Ali, Md. Yousuf
Tanvir, E. M.
Bhoumik, Nikhil Chandra
Paul, Sudip
Gan, Siew Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The antihyperglycemic, antidiabetic, and antioxidant potentials of the methanolic extract of Garcinia pedunculata (GP) fruit in rats were investigated.
The acute antihyperglycemic effect of different doses of GP was studied in normal male Wistar rats.
Diabetes was induced by streptozotocin (STZ) injection in another cohort of male Wistar rats and they showed significantly higher blood glucose and glycated hemoglobin (HbA1c) levels, altered lipid profiles, and lower insulin levels compared to nondiabetic control animals.
There were increased lipid peroxidation and reduced levels of cellular antioxidant enzymes in different tissues of diabetic rats.
However, oral administration of GP extracts, especially the highest dose (1000 mg/kg), significantly ameliorated hyperglycemia (42%); elevated insulin levels (165%); decreased HbA1c (29.4%); restored lipid levels (reduction in TG by 25%, TC by 15%, and LDL-C by 75% and increase in HDL-C by 4%), liver and renal function markers, and lipid peroxidation (reduction by 52% in the liver, 39% in the kidney, 44% in the heart, and 46% in the pancreas); and stimulated tissue antioxidant enzymes to near normalcy.
Overall, the findings suggest that GP fruit is effective against hyperglycemia and could be used in the treatment of diabetes and its complications and other oxidative stress-mediated pathological conditions.
American Psychological Association (APA)
Ali, Md. Yousuf& Paul, Sudip& Tanvir, E. M.& Hossen, Md. Sakib& Rumpa, Nur-E-Noushin& Saha, Moumoni…[et al.]. 2017. Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1153400
Modern Language Association (MLA)
Ali, Md. Yousuf…[et al.]. Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1153400
American Medical Association (AMA)
Ali, Md. Yousuf& Paul, Sudip& Tanvir, E. M.& Hossen, Md. Sakib& Rumpa, Nur-E-Noushin& Saha, Moumoni…[et al.]. Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1153400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153400