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The Hypocholesterolemic Effects of Eryngium carlinae F. Delaroche Are Mediated by the Involvement of the Intestinal Transporters ABCG5 and ABCG8
المؤلفون المشاركون
Naranjo-Rodríguez, Elia Brosla
De la O-Arciniega, Minarda
Castro-Torres, Víctor Alberto
Domínguez-Ortíz, Miguel Ángel
Martínez-Vázquez, Mariano
Castro-Torres, Ibrahim Guillermo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Hypercholesterolemia is a metabolic disorder characterized by a high concentration of cholesterol in the blood.
Eryngium carlinae is a medicinal plant used to treat lipid diseases.
The goal of this work was to evaluate, in a model of hypercholesterolemia in mice, the hypocholesterolemic effect of a hydroalcoholic extract of E.
carlinae and its main metabolite, D-mannitol.
Biochemical analyses of serum lipids and hepatic enzymes were performed by photocolorimetry.
We performed histopathological studies of the liver and the expression of the intestinal cholesterol transporters Abcg5 and Abcg8 was determined by standard western blot method.
Our results showed that hydroalcoholic extract at doses of 100 mg/kg and D-mannitol at doses of 10 mg/kg reduced the concentration of both total cholesterol and non-HDL cholesterol, without altering the concentration of HDL cholesterol and without damage to hepatocytes.
Treatment with the extract increased Abcg8 intestinal transporter expression, while D-mannitol decreased the expression of the two Abcg5/Abcg8 transporters, compared with the hypercholesterolemic group.
Considering that Abcg5/Abcg8 transporters perform cholesterol efflux, our results demonstrate that the lipid-lowering effect of the hydroalcoholic extract may be associated with the increase of Abcg8 expression, but the hypocholesterolemic effect of D-mannitol is independent of overexpression of these intestinal transporters and probably they have another mechanism of action.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Castro-Torres, Ibrahim Guillermo& De la O-Arciniega, Minarda& Naranjo-Rodríguez, Elia Brosla& Castro-Torres, Víctor Alberto& Domínguez-Ortíz, Miguel Ángel& Martínez-Vázquez, Mariano. 2017. The Hypocholesterolemic Effects of Eryngium carlinae F. Delaroche Are Mediated by the Involvement of the Intestinal Transporters ABCG5 and ABCG8. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153454
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Castro-Torres, Ibrahim Guillermo…[et al.]. The Hypocholesterolemic Effects of Eryngium carlinae F. Delaroche Are Mediated by the Involvement of the Intestinal Transporters ABCG5 and ABCG8. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1153454
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Castro-Torres, Ibrahim Guillermo& De la O-Arciniega, Minarda& Naranjo-Rodríguez, Elia Brosla& Castro-Torres, Víctor Alberto& Domínguez-Ortíz, Miguel Ángel& Martínez-Vázquez, Mariano. The Hypocholesterolemic Effects of Eryngium carlinae F. Delaroche Are Mediated by the Involvement of the Intestinal Transporters ABCG5 and ABCG8. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153454
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153454
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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