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The Hypocholesterolemic Effects of Eryngium carlinae F. Delaroche Are Mediated by the Involvement of the Intestinal Transporters ABCG5 and ABCG8
Joint Authors
Naranjo-Rodríguez, Elia Brosla
De la O-Arciniega, Minarda
Castro-Torres, Víctor Alberto
Domínguez-Ortíz, Miguel Ángel
Martínez-Vázquez, Mariano
Castro-Torres, Ibrahim Guillermo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hypercholesterolemia is a metabolic disorder characterized by a high concentration of cholesterol in the blood.
Eryngium carlinae is a medicinal plant used to treat lipid diseases.
The goal of this work was to evaluate, in a model of hypercholesterolemia in mice, the hypocholesterolemic effect of a hydroalcoholic extract of E.
carlinae and its main metabolite, D-mannitol.
Biochemical analyses of serum lipids and hepatic enzymes were performed by photocolorimetry.
We performed histopathological studies of the liver and the expression of the intestinal cholesterol transporters Abcg5 and Abcg8 was determined by standard western blot method.
Our results showed that hydroalcoholic extract at doses of 100 mg/kg and D-mannitol at doses of 10 mg/kg reduced the concentration of both total cholesterol and non-HDL cholesterol, without altering the concentration of HDL cholesterol and without damage to hepatocytes.
Treatment with the extract increased Abcg8 intestinal transporter expression, while D-mannitol decreased the expression of the two Abcg5/Abcg8 transporters, compared with the hypercholesterolemic group.
Considering that Abcg5/Abcg8 transporters perform cholesterol efflux, our results demonstrate that the lipid-lowering effect of the hydroalcoholic extract may be associated with the increase of Abcg8 expression, but the hypocholesterolemic effect of D-mannitol is independent of overexpression of these intestinal transporters and probably they have another mechanism of action.
American Psychological Association (APA)
Castro-Torres, Ibrahim Guillermo& De la O-Arciniega, Minarda& Naranjo-Rodríguez, Elia Brosla& Castro-Torres, Víctor Alberto& Domínguez-Ortíz, Miguel Ángel& Martínez-Vázquez, Mariano. 2017. The Hypocholesterolemic Effects of Eryngium carlinae F. Delaroche Are Mediated by the Involvement of the Intestinal Transporters ABCG5 and ABCG8. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153454
Modern Language Association (MLA)
Castro-Torres, Ibrahim Guillermo…[et al.]. The Hypocholesterolemic Effects of Eryngium carlinae F. Delaroche Are Mediated by the Involvement of the Intestinal Transporters ABCG5 and ABCG8. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1153454
American Medical Association (AMA)
Castro-Torres, Ibrahim Guillermo& De la O-Arciniega, Minarda& Naranjo-Rodríguez, Elia Brosla& Castro-Torres, Víctor Alberto& Domínguez-Ortíz, Miguel Ángel& Martínez-Vázquez, Mariano. The Hypocholesterolemic Effects of Eryngium carlinae F. Delaroche Are Mediated by the Involvement of the Intestinal Transporters ABCG5 and ABCG8. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153454