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Clinical Efficacy and Safety of Total Glucosides of Paeony for Primary Sjögren’s Syndrome: A Systematic Review
المؤلفون المشاركون
Jin, Liang
Li, Chengyin
Li, Yanping
Wu, Bin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the clinical efficacy and safety of total glucosides of paeony (TGP) for primary Sjögren’s syndrome (pSS).
Methods.
Eight electronic databases were searched from their inception to July 2016.
Clinical randomized controlled trials (RCTs) were included.
The study quality was evaluated according to the standard suggested in the Cochrane Handbook.
RevMan 5.1 was used for statistical analysis.
Results.
Seven RCTs involving 443 patients were included.
The results showed that TGP combined with an immunosuppressant (IS) showed greater efficacy for improving the saliva flow test of pSS compared to immunosuppressant alone (WMD −6.88, 95% CI −9.02 to −4.74, and P<0.00001).
And the same trend favouring TGP-IS dual combination was found in Schirmer test (WMD 1.63, 95% CI 0.26 to 3.01, and P=0.02), ESR (WMD 7.33, 95% CI −10.08 to −4.59, and P<0.00001), CRP (WMD −6.00, 95% CI −7.17 to −4.83, and P<0.00001), IgM (WMD = −0.42, 95% CI −0.70 to 0.13, and P=0.004), and IgG (WMD −3.22, 95% CI −4.32 to −2.12, and P<0.00001) analysis.
However, TGP did not affect IgA (WMD 0.53, 95% CI −1.34 to −0.29, and P=0.20).
The adverse events manifested no significant differences between the two groups.
Conclusions.
The TGP-IS combination is superior to IS alone in the treatment of pSS.
However, due to the low quality of included studies, high-quality RCTs are needed to confirm the beneficial effects of TGP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Liang& Li, Chengyin& Li, Yanping& Wu, Bin. 2017. Clinical Efficacy and Safety of Total Glucosides of Paeony for Primary Sjögren’s Syndrome: A Systematic Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153477
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Liang…[et al.]. Clinical Efficacy and Safety of Total Glucosides of Paeony for Primary Sjögren’s Syndrome: A Systematic Review. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153477
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Liang& Li, Chengyin& Li, Yanping& Wu, Bin. Clinical Efficacy and Safety of Total Glucosides of Paeony for Primary Sjögren’s Syndrome: A Systematic Review. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153477
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153477
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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