Clinical Efficacy and Safety of Total Glucosides of Paeony for Primary Sjögren’s Syndrome: A Systematic Review
Joint Authors
Jin, Liang
Li, Chengyin
Li, Yanping
Wu, Bin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To evaluate the clinical efficacy and safety of total glucosides of paeony (TGP) for primary Sjögren’s syndrome (pSS).
Methods.
Eight electronic databases were searched from their inception to July 2016.
Clinical randomized controlled trials (RCTs) were included.
The study quality was evaluated according to the standard suggested in the Cochrane Handbook.
RevMan 5.1 was used for statistical analysis.
Results.
Seven RCTs involving 443 patients were included.
The results showed that TGP combined with an immunosuppressant (IS) showed greater efficacy for improving the saliva flow test of pSS compared to immunosuppressant alone (WMD −6.88, 95% CI −9.02 to −4.74, and P<0.00001).
And the same trend favouring TGP-IS dual combination was found in Schirmer test (WMD 1.63, 95% CI 0.26 to 3.01, and P=0.02), ESR (WMD 7.33, 95% CI −10.08 to −4.59, and P<0.00001), CRP (WMD −6.00, 95% CI −7.17 to −4.83, and P<0.00001), IgM (WMD = −0.42, 95% CI −0.70 to 0.13, and P=0.004), and IgG (WMD −3.22, 95% CI −4.32 to −2.12, and P<0.00001) analysis.
However, TGP did not affect IgA (WMD 0.53, 95% CI −1.34 to −0.29, and P=0.20).
The adverse events manifested no significant differences between the two groups.
Conclusions.
The TGP-IS combination is superior to IS alone in the treatment of pSS.
However, due to the low quality of included studies, high-quality RCTs are needed to confirm the beneficial effects of TGP.
American Psychological Association (APA)
Jin, Liang& Li, Chengyin& Li, Yanping& Wu, Bin. 2017. Clinical Efficacy and Safety of Total Glucosides of Paeony for Primary Sjögren’s Syndrome: A Systematic Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153477
Modern Language Association (MLA)
Jin, Liang…[et al.]. Clinical Efficacy and Safety of Total Glucosides of Paeony for Primary Sjögren’s Syndrome: A Systematic Review. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153477
American Medical Association (AMA)
Jin, Liang& Li, Chengyin& Li, Yanping& Wu, Bin. Clinical Efficacy and Safety of Total Glucosides of Paeony for Primary Sjögren’s Syndrome: A Systematic Review. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153477