Correlation between miR-200 Family Overexpression and Cancer Prognosis
المؤلفون المشاركون
Liu, Wen
Zhang, Kaiping
Hu, Yue
Peng, Yaqin
Fang, Xiang
He, Guoping
Wu, Limin
Chao, Min
Wang, Jing
Wei, Pengfei
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-04
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
The correlation between miR-200 family overexpression and cancer prognosis remains controversial.
Therefore, we conducted a systematic review and meta-analysis by searching PubMed, Embase, Cochrane Library, China Biology Medicine disc (CBM), and China National Knowledge Infrastructure (CNKI) to identify eligible studies.
Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the correlations.
Additionally, different subgroup analyses and publication bias test were performed.
Eventually, we analyzed 23 articles that included five tumor types and 3038 patients.
Consequently, high expression of miR-200 family in various tumors was associated with unfavorable overall survival (OS) in both univariate (HR=1.32, 95% CI: 1.14–1.54, P<0.001) and multivariate (HR=1.32, 95% CI: 1.16–1.49, P<0.001) analyses.
Likewise, a similar result was found in different subgroups of the patient source, cancer type, test method, sample source, miR-200 component, and sample size.
However, no association of miR-200 family was detected with recurrence- or relapse-free survival (RFS) (univariate: HR=1.02, 95% CI: 0.96–1.09, P=0.47; multivariate: HR=1.07, 95% CI: 1.00–1.14, P=0.07), progression-free survival (PFS) (univariate: HR=0.96, 95% CI: 0.54–1.70, P=0.88; multivariate: HR=1.17, 95% CI: 0.86–1.61, P=0.32), and disease-free survival (DFS) (univariate: HR=0.90, 95% CI: 0.74–1.09, P=0.29; multivariate: HR=0.98, 95% CI: 0.68–1.41, P=0.90).
Our findings have provided convincing evidence that miR-200 family overexpression suggested poor prognosis of various cancer types, which efforts may raise the potential use of miR-200 family for cancer prognosis in clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Wen& Zhang, Kaiping& Wei, Pengfei& Hu, Yue& Peng, Yaqin& Fang, Xiang…[et al.]. 2018. Correlation between miR-200 Family Overexpression and Cancer Prognosis. Disease Markers،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1153485
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Wen…[et al.]. Correlation between miR-200 Family Overexpression and Cancer Prognosis. Disease Markers No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1153485
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Wen& Zhang, Kaiping& Wei, Pengfei& Hu, Yue& Peng, Yaqin& Fang, Xiang…[et al.]. Correlation between miR-200 Family Overexpression and Cancer Prognosis. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1153485
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153485
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر