Correlation between miR-200 Family Overexpression and Cancer Prognosis
Joint Authors
Liu, Wen
Zhang, Kaiping
Hu, Yue
Peng, Yaqin
Fang, Xiang
He, Guoping
Wu, Limin
Chao, Min
Wang, Jing
Wei, Pengfei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The correlation between miR-200 family overexpression and cancer prognosis remains controversial.
Therefore, we conducted a systematic review and meta-analysis by searching PubMed, Embase, Cochrane Library, China Biology Medicine disc (CBM), and China National Knowledge Infrastructure (CNKI) to identify eligible studies.
Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the correlations.
Additionally, different subgroup analyses and publication bias test were performed.
Eventually, we analyzed 23 articles that included five tumor types and 3038 patients.
Consequently, high expression of miR-200 family in various tumors was associated with unfavorable overall survival (OS) in both univariate (HR=1.32, 95% CI: 1.14–1.54, P<0.001) and multivariate (HR=1.32, 95% CI: 1.16–1.49, P<0.001) analyses.
Likewise, a similar result was found in different subgroups of the patient source, cancer type, test method, sample source, miR-200 component, and sample size.
However, no association of miR-200 family was detected with recurrence- or relapse-free survival (RFS) (univariate: HR=1.02, 95% CI: 0.96–1.09, P=0.47; multivariate: HR=1.07, 95% CI: 1.00–1.14, P=0.07), progression-free survival (PFS) (univariate: HR=0.96, 95% CI: 0.54–1.70, P=0.88; multivariate: HR=1.17, 95% CI: 0.86–1.61, P=0.32), and disease-free survival (DFS) (univariate: HR=0.90, 95% CI: 0.74–1.09, P=0.29; multivariate: HR=0.98, 95% CI: 0.68–1.41, P=0.90).
Our findings have provided convincing evidence that miR-200 family overexpression suggested poor prognosis of various cancer types, which efforts may raise the potential use of miR-200 family for cancer prognosis in clinical practice.
American Psychological Association (APA)
Liu, Wen& Zhang, Kaiping& Wei, Pengfei& Hu, Yue& Peng, Yaqin& Fang, Xiang…[et al.]. 2018. Correlation between miR-200 Family Overexpression and Cancer Prognosis. Disease Markers،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1153485
Modern Language Association (MLA)
Liu, Wen…[et al.]. Correlation between miR-200 Family Overexpression and Cancer Prognosis. Disease Markers No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1153485
American Medical Association (AMA)
Liu, Wen& Zhang, Kaiping& Wei, Pengfei& Hu, Yue& Peng, Yaqin& Fang, Xiang…[et al.]. Correlation between miR-200 Family Overexpression and Cancer Prognosis. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1153485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153485