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Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
المؤلفون المشاركون
Goncalves, Marilda Souza
Santiago, Rayra Pereira
Yahouédéhou, Sètondji Cocou Modeste Alexandre
Ferreira, Junia Raquel Dutra
Adorno, Elisângela Vitoria
Guarda, Caroline Conceição
Aleluia, Milena Magalhães
Carvalho, Magda Oliveira Seixas
Oliveira, Rodrigo Mota
Carvalho, Suellen Pinheiro
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters in sickle cell anemia patients under hydroxyurea (SCA-HU+).
We evaluated hematologic and biochemical parameters by electronic methods and SNPs by PCR-RFLP and multiplex PCR in 35 SCA-HU+ patients and 67 SCA-HU− patients.
The HbS, total cholesterol, lactate dehydrogenase, aspartate aminotransferase, total bilirubin and fractions levels, and leukocyte, eosinophil, monocyte, and erythroblast counts were reduced in SCA-HU+ patients (p<0.05).
Moreover, they presented higher HbF, C-reactive protein, and ferritin levels and elevated MCH and MCV values (p<0.05).
Genotype frequencies of variants GA + AA of MPO −463G>A and c1c2 + c2c2 of CYP2E1 −1293G>C/−1053C>T were higher in SCA-HU+ patients (p<0.05).
Independent associations were found between the variant A allele and lower total cholesterol, between c2 allele and low alpha-1 antitrypsin and between the null GSTT1 variant and high indirect and total bilirubin in SCA-HU+ patients.
In SCA-HU− patients, independent associations were found between the variant A allele and high uric acid and between c2 allele and high urea.
Our results suggest that SNPs MPO −463G>A, CYP2E1 −1293G>C/−1053C>T, and GSTT1 can be associated with alterations in lipid, inflammatory, renal, hemolytic, and hepatic profiles.
However, further studies are needed to elucidate these associations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yahouédéhou, Sètondji Cocou Modeste Alexandre& Carvalho, Magda Oliveira Seixas& Oliveira, Rodrigo Mota& Santiago, Rayra Pereira& Guarda, Caroline Conceição& Carvalho, Suellen Pinheiro…[et al.]. 2018. Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters. Disease Markers،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153489
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yahouédéhou, Sètondji Cocou Modeste Alexandre…[et al.]. Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters. Disease Markers No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1153489
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yahouédéhou, Sètondji Cocou Modeste Alexandre& Carvalho, Magda Oliveira Seixas& Oliveira, Rodrigo Mota& Santiago, Rayra Pereira& Guarda, Caroline Conceição& Carvalho, Suellen Pinheiro…[et al.]. Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153489
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153489
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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