Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
Joint Authors
Goncalves, Marilda Souza
Santiago, Rayra Pereira
Yahouédéhou, Sètondji Cocou Modeste Alexandre
Ferreira, Junia Raquel Dutra
Adorno, Elisângela Vitoria
Guarda, Caroline Conceição
Aleluia, Milena Magalhães
Carvalho, Magda Oliveira Seixas
Oliveira, Rodrigo Mota
Carvalho, Suellen Pinheiro
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters in sickle cell anemia patients under hydroxyurea (SCA-HU+).
We evaluated hematologic and biochemical parameters by electronic methods and SNPs by PCR-RFLP and multiplex PCR in 35 SCA-HU+ patients and 67 SCA-HU− patients.
The HbS, total cholesterol, lactate dehydrogenase, aspartate aminotransferase, total bilirubin and fractions levels, and leukocyte, eosinophil, monocyte, and erythroblast counts were reduced in SCA-HU+ patients (p<0.05).
Moreover, they presented higher HbF, C-reactive protein, and ferritin levels and elevated MCH and MCV values (p<0.05).
Genotype frequencies of variants GA + AA of MPO −463G>A and c1c2 + c2c2 of CYP2E1 −1293G>C/−1053C>T were higher in SCA-HU+ patients (p<0.05).
Independent associations were found between the variant A allele and lower total cholesterol, between c2 allele and low alpha-1 antitrypsin and between the null GSTT1 variant and high indirect and total bilirubin in SCA-HU+ patients.
In SCA-HU− patients, independent associations were found between the variant A allele and high uric acid and between c2 allele and high urea.
Our results suggest that SNPs MPO −463G>A, CYP2E1 −1293G>C/−1053C>T, and GSTT1 can be associated with alterations in lipid, inflammatory, renal, hemolytic, and hepatic profiles.
However, further studies are needed to elucidate these associations.
American Psychological Association (APA)
Yahouédéhou, Sètondji Cocou Modeste Alexandre& Carvalho, Magda Oliveira Seixas& Oliveira, Rodrigo Mota& Santiago, Rayra Pereira& Guarda, Caroline Conceição& Carvalho, Suellen Pinheiro…[et al.]. 2018. Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters. Disease Markers،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153489
Modern Language Association (MLA)
Yahouédéhou, Sètondji Cocou Modeste Alexandre…[et al.]. Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters. Disease Markers No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1153489
American Medical Association (AMA)
Yahouédéhou, Sètondji Cocou Modeste Alexandre& Carvalho, Magda Oliveira Seixas& Oliveira, Rodrigo Mota& Santiago, Rayra Pereira& Guarda, Caroline Conceição& Carvalho, Suellen Pinheiro…[et al.]. Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153489
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153489