Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases
المؤلفون المشاركون
Niki, Hanako
Kishimoto, Yoshimi
Saita, Emi
Ohmori, Reiko
Kondo, Kazuo
Momiyama, Yukihiko
Ibe, Susumu
Sasaki, Kenji
Miura, Kotaro
Ikegami, Yukinori
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate CO, biliverdin, and iron.
Since these products have antiatherogenic properties, HO-1 may play a protective role against the progression of atherosclerosis.
However, plasma HO-1 levels in patients with atherosclerotic diseases, such as coronary artery disease (CAD) and peripheral artery disease (PAD), have not been clarified yet.
Methods.
We investigated plasma HO-1 levels by ELISA in 410 consecutive patients undergoing elective coronary angiography who also had an ankle-brachial index (ABI) test for PAD screening.
Results.
Of the 410 study patients, CAD was present in 225 patients (55%) (1-vessel (1-VD), n=91; 2-vessel (2-VD), n=66; 3-vessel disease (3-VD), n=68).
PAD (ABI < 0.9) was found in 36 (9%) patients.
Plasma HO-1 levels did not differ between 225 patients with CAD and 185 without CAD (median 0.44 versus 0.35 ng/mL), but they were significantly lower in 36 patients with PAD than in 374 without PAD (0.27 versus 0.41 ng/mL, P<0.02).
After excluding the 36 patients with PAD, HO-1 levels were significantly higher in 192 patients with CAD than in 182 without CAD (0.45 versus 0.35 ng/mL, P<0.05).
HO-1 levels in 4 groups of CAD(−), 1-VD, 2-VD, and 3-VD were 0.35, 0.49, 0.44, and 0.44 ng/mL, respectively, and were highest in 1-VD (P<0.05).
In the multivariate analysis, HO-1 levels were inversely associated with PAD, whereas they were also associated with CAD.
The odds ratios for PAD and CAD were 2.12 (95% CI = 1.03–4.37) and 0.65 (95% CI = 0.42–0.99) for the HO-1 level of <0.35 ng/mL, respectively.
Conclusions.
Plasma HO-1 levels were found to be low in patients with PAD, in contrast to high levels in patients with CAD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kishimoto, Yoshimi& Ibe, Susumu& Saita, Emi& Sasaki, Kenji& Niki, Hanako& Miura, Kotaro…[et al.]. 2018. Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases. Disease Markers،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153492
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kishimoto, Yoshimi…[et al.]. Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases. Disease Markers No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153492
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kishimoto, Yoshimi& Ibe, Susumu& Saita, Emi& Sasaki, Kenji& Niki, Hanako& Miura, Kotaro…[et al.]. Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153492
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153492
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر