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Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases
Joint Authors
Niki, Hanako
Kishimoto, Yoshimi
Saita, Emi
Ohmori, Reiko
Kondo, Kazuo
Momiyama, Yukihiko
Ibe, Susumu
Sasaki, Kenji
Miura, Kotaro
Ikegami, Yukinori
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate CO, biliverdin, and iron.
Since these products have antiatherogenic properties, HO-1 may play a protective role against the progression of atherosclerosis.
However, plasma HO-1 levels in patients with atherosclerotic diseases, such as coronary artery disease (CAD) and peripheral artery disease (PAD), have not been clarified yet.
Methods.
We investigated plasma HO-1 levels by ELISA in 410 consecutive patients undergoing elective coronary angiography who also had an ankle-brachial index (ABI) test for PAD screening.
Results.
Of the 410 study patients, CAD was present in 225 patients (55%) (1-vessel (1-VD), n=91; 2-vessel (2-VD), n=66; 3-vessel disease (3-VD), n=68).
PAD (ABI < 0.9) was found in 36 (9%) patients.
Plasma HO-1 levels did not differ between 225 patients with CAD and 185 without CAD (median 0.44 versus 0.35 ng/mL), but they were significantly lower in 36 patients with PAD than in 374 without PAD (0.27 versus 0.41 ng/mL, P<0.02).
After excluding the 36 patients with PAD, HO-1 levels were significantly higher in 192 patients with CAD than in 182 without CAD (0.45 versus 0.35 ng/mL, P<0.05).
HO-1 levels in 4 groups of CAD(−), 1-VD, 2-VD, and 3-VD were 0.35, 0.49, 0.44, and 0.44 ng/mL, respectively, and were highest in 1-VD (P<0.05).
In the multivariate analysis, HO-1 levels were inversely associated with PAD, whereas they were also associated with CAD.
The odds ratios for PAD and CAD were 2.12 (95% CI = 1.03–4.37) and 0.65 (95% CI = 0.42–0.99) for the HO-1 level of <0.35 ng/mL, respectively.
Conclusions.
Plasma HO-1 levels were found to be low in patients with PAD, in contrast to high levels in patients with CAD.
American Psychological Association (APA)
Kishimoto, Yoshimi& Ibe, Susumu& Saita, Emi& Sasaki, Kenji& Niki, Hanako& Miura, Kotaro…[et al.]. 2018. Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases. Disease Markers،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153492
Modern Language Association (MLA)
Kishimoto, Yoshimi…[et al.]. Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases. Disease Markers No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153492
American Medical Association (AMA)
Kishimoto, Yoshimi& Ibe, Susumu& Saita, Emi& Sasaki, Kenji& Niki, Hanako& Miura, Kotaro…[et al.]. Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153492