Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in Patients Newly Diagnosed with Type 2 Diabetes Mellitus
المؤلفون المشاركون
Yan, Pijun
Wan, Qin
Feng, Jian
Li, Hua
Yang, Jun
Zhong, Haihua
Xu, Yong
Zhang, Zhihong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Neuregulin 4 (Nrg4) has been proposed to play a role in the pathogeneses of obesity, insulin resistance, and dyslipidemia.
However, information about the link between Nrg4 and metabolic syndrome (MetS) is scarce, especially in patients with newly diagnosed type 2 diabetes mellitus (nT2DM).
This study aimed at investigating whether Nrg4 is associated with MetS in nT2DM patients.
A total of 311 patients with nT2DM were recruited.
Plasma Nrg4 concentration was determined by ELISA.
Plasma Nrg4 concentration was lower in nT2DM patients with MetS than in nT2DM patients without MetS (P=0.001).
Nrg4 concentration showed negative correlations with most of the analyzed indicators of MetS.
MetS was less prevalent among subjects in the highest quartile of plasma Nrg4 concentration than among those in the lowest quartile (P<0.01).
Age- and sex-adjusted plasma Nrg4 concentrations were positively correlated with concentrations of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A (both P<0.05) and negatively correlated with triglyceride, high-sensitivity C-reactive protein (hs-CRP), and gamma-glutamyltransferase concentrations, neutrophil count, and white blood cell (WBC) count (all P<0.05).
In multivariate analysis, Nrg4 was independently associated with hs-CRP level, WBC count, and HDL-C level (P=0.001 or P<0.05).
Multiple logistic regression analysis of MetS prediction by Nrg4 revealed an odds ratio of 0.560 (95% CI: 0.374–0.837; P<0.01).
Decreased plasma Nrg4 levels, which may be associated with augmented oxidative stress, inflammation, and dyslipidemia, might be involved in the development of MetS in nT2DM patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yan, Pijun& Xu, Yong& Wan, Qin& Feng, Jian& Li, Hua& Yang, Jun…[et al.]. 2018. Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in Patients Newly Diagnosed with Type 2 Diabetes Mellitus. Disease Markers،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153568
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yan, Pijun…[et al.]. Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in Patients Newly Diagnosed with Type 2 Diabetes Mellitus. Disease Markers No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1153568
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yan, Pijun& Xu, Yong& Wan, Qin& Feng, Jian& Li, Hua& Yang, Jun…[et al.]. Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in Patients Newly Diagnosed with Type 2 Diabetes Mellitus. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153568
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153568
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر