Electroacupuncture at ST36 Protects ICC Networks via mSCFKit-ETV1 Signaling in the Stomach of Diabetic Mice
المؤلفون المشاركون
Tian, Lugao
Zhu, Beibei
Liu, Shi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-22
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Electroacupuncture (EA) at ST36 has been used to regulate gastric motility and effectively improve gastric emptying in diabetic patients.
Nevertheless, the specific mechanisms underlying the efficacy of this treatment remain unknown.
The aim of this study was to assess the variations of interstitial cells of Cajal (ICC) and explore the changes in mSCF/KIT-ETV1 signaling in the antrum and corpus of diabetic mice after treatment with EA.
Methods.
Male C57BL/6 mice were randomized into five groups: control group, diabetic group (DM), diabetic-plus-sham EA group (SEA), diabetic-plus-low-frequency EA group (LEA), and diabetic-plus-high-frequency EA group (HEA).
The expression levels of Ano1, c-Kit, and ETV1 were assessed by immunofluorescence in the antrum and corpus.
Western blotting and PCR methods were further used to evaluate c-Kit, mSCF, and ETV1 expression.
Results.
(1) c-Kit and Ano1 were obviously decreased in the DM group, but c-Kit reduced much more than Ano1.
(2) The mSCF, c-Kit, and ETV1 mRNA and protein levels were obviously decreased in the DM group in both the antrum and the corpus (P<0.01), but they were significantly elevated in the LEA and HEA groups (P<0.01).
Conclusions.
Ano1 is a reliable marker to detect ICC changes in diabetes; low- and high-frequency EA at acupoint ST36 can protect the networks of ICC possibly via normal activation of mSCF/KIT-ETV1 signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Lugao& Zhu, Beibei& Liu, Shi. 2017. Electroacupuncture at ST36 Protects ICC Networks via mSCFKit-ETV1 Signaling in the Stomach of Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153613
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Lugao…[et al.]. Electroacupuncture at ST36 Protects ICC Networks via mSCFKit-ETV1 Signaling in the Stomach of Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1153613
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Lugao& Zhu, Beibei& Liu, Shi. Electroacupuncture at ST36 Protects ICC Networks via mSCFKit-ETV1 Signaling in the Stomach of Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153613
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153613
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر