Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation
المؤلفون المشاركون
Etoa, François-Xavier
Fonkoua, Marie-Christine
Nyegue, Maximilienne A.
Afagnigni, Alian D.
Ndoye Foe, Chantal Florentine
Njankouo Ndam, Youchahou
Njayou, Frédéric Nico
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D.
multiflora) on Shigella flexneri-induced diarrhea in Wistar rats and its subacute toxicity.
Diarrhea was induced by oral administration of 1.2 × 109 cells/mL S.
flexneri to rats.
Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg.
The level of biochemical parameters was assessed and organs histology examined by 14 days’ subacute toxicity.
S.
flexneri stool load decreased significantly in dose-dependent manner.
The level of ALT increased (p<0.05) in male rats treated with the dose of 445.68 mg/kg while creatinine level increased in rats treated with both doses.
In female rats, a significant decrease (p<0.05) of the level of AST and creatinine was noted in rats treated with the dose of 222.84 mg/kg of D.
multiflora.
Histological exams of kidney and liver of treated rats showed architectural modifications at the dose of 445.68 mg/kg.
This finding suggests that D.
multiflora leaf extract is efficient against diarrhea caused by S.
flexneri but the treatment with doses lower than 222.84 mg/kg is recommended while further study is required to define the exact efficient nontoxic dose.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Afagnigni, Alian D.& Nyegue, Maximilienne A.& Ndoye Foe, Chantal Florentine& Njankouo Ndam, Youchahou& Njayou, Frédéric Nico& Fonkoua, Marie-Christine…[et al.]. 2017. Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153641
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Afagnigni, Alian D.…[et al.]. Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153641
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Afagnigni, Alian D.& Nyegue, Maximilienne A.& Ndoye Foe, Chantal Florentine& Njankouo Ndam, Youchahou& Njayou, Frédéric Nico& Fonkoua, Marie-Christine…[et al.]. Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153641
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153641
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر