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Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation
Joint Authors
Etoa, François-Xavier
Fonkoua, Marie-Christine
Nyegue, Maximilienne A.
Afagnigni, Alian D.
Ndoye Foe, Chantal Florentine
Njankouo Ndam, Youchahou
Njayou, Frédéric Nico
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D.
multiflora) on Shigella flexneri-induced diarrhea in Wistar rats and its subacute toxicity.
Diarrhea was induced by oral administration of 1.2 × 109 cells/mL S.
flexneri to rats.
Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg.
The level of biochemical parameters was assessed and organs histology examined by 14 days’ subacute toxicity.
S.
flexneri stool load decreased significantly in dose-dependent manner.
The level of ALT increased (p<0.05) in male rats treated with the dose of 445.68 mg/kg while creatinine level increased in rats treated with both doses.
In female rats, a significant decrease (p<0.05) of the level of AST and creatinine was noted in rats treated with the dose of 222.84 mg/kg of D.
multiflora.
Histological exams of kidney and liver of treated rats showed architectural modifications at the dose of 445.68 mg/kg.
This finding suggests that D.
multiflora leaf extract is efficient against diarrhea caused by S.
flexneri but the treatment with doses lower than 222.84 mg/kg is recommended while further study is required to define the exact efficient nontoxic dose.
American Psychological Association (APA)
Afagnigni, Alian D.& Nyegue, Maximilienne A.& Ndoye Foe, Chantal Florentine& Njankouo Ndam, Youchahou& Njayou, Frédéric Nico& Fonkoua, Marie-Christine…[et al.]. 2017. Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153641
Modern Language Association (MLA)
Afagnigni, Alian D.…[et al.]. Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153641
American Medical Association (AMA)
Afagnigni, Alian D.& Nyegue, Maximilienne A.& Ndoye Foe, Chantal Florentine& Njankouo Ndam, Youchahou& Njayou, Frédéric Nico& Fonkoua, Marie-Christine…[et al.]. Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153641
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153641