Investigating Potential Modes of Actions of Mimusops kummel Fruit Extract and Solvent Fractions for Their Antidiarrheal Activities in Mice
المؤلفون المشاركون
Abay, Solomon M.
Molla, Mulugeta
Gemeda, Negero
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Fruits of Mimusops kummel A.
DC.
(Sapotaceae) are traditionally used for the treatment of diarrhea.
The present study aimed at investigating modes of actions of this fruits for antidiarrheal action to guide future drug development process.
Methods.
Fractions of chloroform, n-butanol, and water were obtained from 80% methanol extract, which was prepared by maceration.
Antidiarrheal activities and the modes of actions were investigated in mice.
Results.
In castor oil induced diarrheal model, the extract delayed onset of diarrhea and reduced number and weight of feces at all tested doses significantly.
In this model all fractions significantly delayed onset of diarrhea at all tested doses.
Charcoal meal test showed that the extract and all the fractions produced a significant antimotility effect at all tested doses.
Enteropooling test showed that the extract as well as n-butanol and aqueous fractions at all tested doses produced a significant decline in volume and weight of intestinal contents, whereas chloroform fraction had substantial effect only at high dose.
Conclusion.
This study demonstrated that the extract and solvent fractions produced antidiarrheal activities due to dual inhibitory effect, intestinal motility, and fluid secretion, with the aqueous fraction being the most active among fractions in three models.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Molla, Mulugeta& Gemeda, Negero& Abay, Solomon M.. 2017. Investigating Potential Modes of Actions of Mimusops kummel Fruit Extract and Solvent Fractions for Their Antidiarrheal Activities in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153670
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Molla, Mulugeta…[et al.]. Investigating Potential Modes of Actions of Mimusops kummel Fruit Extract and Solvent Fractions for Their Antidiarrheal Activities in Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153670
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Molla, Mulugeta& Gemeda, Negero& Abay, Solomon M.. Investigating Potential Modes of Actions of Mimusops kummel Fruit Extract and Solvent Fractions for Their Antidiarrheal Activities in Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153670
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153670
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر