Investigating Potential Modes of Actions of Mimusops kummel Fruit Extract and Solvent Fractions for Their Antidiarrheal Activities in Mice
Joint Authors
Abay, Solomon M.
Molla, Mulugeta
Gemeda, Negero
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Fruits of Mimusops kummel A.
DC.
(Sapotaceae) are traditionally used for the treatment of diarrhea.
The present study aimed at investigating modes of actions of this fruits for antidiarrheal action to guide future drug development process.
Methods.
Fractions of chloroform, n-butanol, and water were obtained from 80% methanol extract, which was prepared by maceration.
Antidiarrheal activities and the modes of actions were investigated in mice.
Results.
In castor oil induced diarrheal model, the extract delayed onset of diarrhea and reduced number and weight of feces at all tested doses significantly.
In this model all fractions significantly delayed onset of diarrhea at all tested doses.
Charcoal meal test showed that the extract and all the fractions produced a significant antimotility effect at all tested doses.
Enteropooling test showed that the extract as well as n-butanol and aqueous fractions at all tested doses produced a significant decline in volume and weight of intestinal contents, whereas chloroform fraction had substantial effect only at high dose.
Conclusion.
This study demonstrated that the extract and solvent fractions produced antidiarrheal activities due to dual inhibitory effect, intestinal motility, and fluid secretion, with the aqueous fraction being the most active among fractions in three models.
American Psychological Association (APA)
Molla, Mulugeta& Gemeda, Negero& Abay, Solomon M.. 2017. Investigating Potential Modes of Actions of Mimusops kummel Fruit Extract and Solvent Fractions for Their Antidiarrheal Activities in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153670
Modern Language Association (MLA)
Molla, Mulugeta…[et al.]. Investigating Potential Modes of Actions of Mimusops kummel Fruit Extract and Solvent Fractions for Their Antidiarrheal Activities in Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153670
American Medical Association (AMA)
Molla, Mulugeta& Gemeda, Negero& Abay, Solomon M.. Investigating Potential Modes of Actions of Mimusops kummel Fruit Extract and Solvent Fractions for Their Antidiarrheal Activities in Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153670