Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases

المؤلفون المشاركون

Ling, Chang-Quan
Du, Juan
Cheng, Binbin
Yin, Zifei
Liang, Shufang
Zhong, Maofeng
Liu, Dong
Liu, Xiaolin
Zhang, Yani
Wang, Yuan

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-09-26

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

Traditional Chinese medicine formulates treatment according to body constitution (BC) differentiation.

Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases.

This study aimed to assess the characteristic genes of gan-shen Yin deficiency constitution in different diseases.

Fifty primary liver cancer (PLC) patients, 94 hypertension (HBP) patients, and 100 diabetes mellitus (DM) patients were enrolled and classified into gan-shen Yin deficiency group and non-gan-shen Yin deficiency group according to the body constitution questionnaire to assess the clinical manifestation of patients.

The mRNA expressions of 17 genes in PLC patients with gan-shen Yin deficiency were different from those without gan-shen Yin deficiency.

However, considering all patients with PLC, HBP, and DM, only MLH3 was significantly lower in gan-shen Yin deficiency group than that in non-gen-shen Yin deficiency.

By ROC analysis, the relationship between MLH3 and gan-shen Yin deficiency constitution was confirmed.

Treatment of MLH3 (−/− and −/+) mice with Liuweidihuang wan, classical prescriptions for Yin deficiency, partly ameliorates the body constitution of Yin deficiency in MLH3 (−/+) mice, but not in MLH3 (−/−) mice.

MLH3 might be one of material bases of gan-shen Yin deficiency constitution.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Du, Juan& Zhong, Maofeng& Liu, Dong& Liang, Shufang& Liu, Xiaolin& Cheng, Binbin…[et al.]. 2017. Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1153673

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Du, Juan…[et al.]. Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1153673

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Du, Juan& Zhong, Maofeng& Liu, Dong& Liang, Shufang& Liu, Xiaolin& Cheng, Binbin…[et al.]. Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1153673

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1153673