Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases
Joint Authors
Ling, Chang-Quan
Du, Juan
Cheng, Binbin
Yin, Zifei
Liang, Shufang
Zhong, Maofeng
Liu, Dong
Liu, Xiaolin
Zhang, Yani
Wang, Yuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Traditional Chinese medicine formulates treatment according to body constitution (BC) differentiation.
Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases.
This study aimed to assess the characteristic genes of gan-shen Yin deficiency constitution in different diseases.
Fifty primary liver cancer (PLC) patients, 94 hypertension (HBP) patients, and 100 diabetes mellitus (DM) patients were enrolled and classified into gan-shen Yin deficiency group and non-gan-shen Yin deficiency group according to the body constitution questionnaire to assess the clinical manifestation of patients.
The mRNA expressions of 17 genes in PLC patients with gan-shen Yin deficiency were different from those without gan-shen Yin deficiency.
However, considering all patients with PLC, HBP, and DM, only MLH3 was significantly lower in gan-shen Yin deficiency group than that in non-gen-shen Yin deficiency.
By ROC analysis, the relationship between MLH3 and gan-shen Yin deficiency constitution was confirmed.
Treatment of MLH3 (−/− and −/+) mice with Liuweidihuang wan, classical prescriptions for Yin deficiency, partly ameliorates the body constitution of Yin deficiency in MLH3 (−/+) mice, but not in MLH3 (−/−) mice.
MLH3 might be one of material bases of gan-shen Yin deficiency constitution.
American Psychological Association (APA)
Du, Juan& Zhong, Maofeng& Liu, Dong& Liang, Shufang& Liu, Xiaolin& Cheng, Binbin…[et al.]. 2017. Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1153673
Modern Language Association (MLA)
Du, Juan…[et al.]. Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1153673
American Medical Association (AMA)
Du, Juan& Zhong, Maofeng& Liu, Dong& Liang, Shufang& Liu, Xiaolin& Cheng, Binbin…[et al.]. Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1153673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153673