Yangyin Runchang Decoction Improves Intestinal Motility in Mice with AtropineDiphenoxylate-Induced Slow-Transit Constipation
المؤلفون المشاركون
Chen, Yugen
Jiang, Feng
Zhou, Jin-Yong
Wu, Jian
Tian, Fang
Zhu, Xuan-Xuan
Zhu, Chang-Le
Yang, Bo-Lin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This study assessed the efficacy and mechanism of action of Yangyin Runchang decoction (YRD) in the treatment of slow-transit constipation (STC).
ICR mice were randomly divided into four groups (n=10/group) and treated with saline (normal control; NC), atropine/diphenoxylate (model control; MC; 20 mg/kg), or atropine/diphenoxylate plus low-dose YRD (L-YRD; 29.6 g/kg) or high-dose YRD (H-YRD; 59.2 g/kg).
Intestinal motility was assessed by evaluating feces and the intestinal transit rate (ITR).
The serum level of stem cell factor (SCF) and changes in interstitial cells of Cajal (ICCs) were also evaluated.
Additionally, the expression of SCF and c-kit and the intracellular Ca2+ concentration [Ca2+]I were investigated.
Fecal volume and ITR were greater in the L-YRD and H-YRD groups than in the MC group.
The serum SCF level was lower in the MC group than in the NC group; this effect was ameliorated in the YRD-treated mice.
Additionally, YRD-treated mice had more ICCs and elevated expression of c-kit and membrane-bound SCF, and YRD also increased [Ca2+]I in vitro in isolated ICCs.
YRD treatment in this STC mouse model was effective, possibly via the restoration of the SCF/c-kit pathway, increase in the ICC count, and enhancement of ICC function by increasing [Ca2+]i.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Feng& Zhou, Jin-Yong& Wu, Jian& Tian, Fang& Zhu, Xuan-Xuan& Zhu, Chang-Le…[et al.]. 2017. Yangyin Runchang Decoction Improves Intestinal Motility in Mice with AtropineDiphenoxylate-Induced Slow-Transit Constipation. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153699
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Feng…[et al.]. Yangyin Runchang Decoction Improves Intestinal Motility in Mice with AtropineDiphenoxylate-Induced Slow-Transit Constipation. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153699
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Feng& Zhou, Jin-Yong& Wu, Jian& Tian, Fang& Zhu, Xuan-Xuan& Zhu, Chang-Le…[et al.]. Yangyin Runchang Decoction Improves Intestinal Motility in Mice with AtropineDiphenoxylate-Induced Slow-Transit Constipation. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153699
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153699
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر