![](/images/graphics-bg.png)
Yangyin Runchang Decoction Improves Intestinal Motility in Mice with AtropineDiphenoxylate-Induced Slow-Transit Constipation
Joint Authors
Chen, Yugen
Jiang, Feng
Zhou, Jin-Yong
Wu, Jian
Tian, Fang
Zhu, Xuan-Xuan
Zhu, Chang-Le
Yang, Bo-Lin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study assessed the efficacy and mechanism of action of Yangyin Runchang decoction (YRD) in the treatment of slow-transit constipation (STC).
ICR mice were randomly divided into four groups (n=10/group) and treated with saline (normal control; NC), atropine/diphenoxylate (model control; MC; 20 mg/kg), or atropine/diphenoxylate plus low-dose YRD (L-YRD; 29.6 g/kg) or high-dose YRD (H-YRD; 59.2 g/kg).
Intestinal motility was assessed by evaluating feces and the intestinal transit rate (ITR).
The serum level of stem cell factor (SCF) and changes in interstitial cells of Cajal (ICCs) were also evaluated.
Additionally, the expression of SCF and c-kit and the intracellular Ca2+ concentration [Ca2+]I were investigated.
Fecal volume and ITR were greater in the L-YRD and H-YRD groups than in the MC group.
The serum SCF level was lower in the MC group than in the NC group; this effect was ameliorated in the YRD-treated mice.
Additionally, YRD-treated mice had more ICCs and elevated expression of c-kit and membrane-bound SCF, and YRD also increased [Ca2+]I in vitro in isolated ICCs.
YRD treatment in this STC mouse model was effective, possibly via the restoration of the SCF/c-kit pathway, increase in the ICC count, and enhancement of ICC function by increasing [Ca2+]i.
American Psychological Association (APA)
Jiang, Feng& Zhou, Jin-Yong& Wu, Jian& Tian, Fang& Zhu, Xuan-Xuan& Zhu, Chang-Le…[et al.]. 2017. Yangyin Runchang Decoction Improves Intestinal Motility in Mice with AtropineDiphenoxylate-Induced Slow-Transit Constipation. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153699
Modern Language Association (MLA)
Jiang, Feng…[et al.]. Yangyin Runchang Decoction Improves Intestinal Motility in Mice with AtropineDiphenoxylate-Induced Slow-Transit Constipation. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153699
American Medical Association (AMA)
Jiang, Feng& Zhou, Jin-Yong& Wu, Jian& Tian, Fang& Zhu, Xuan-Xuan& Zhu, Chang-Le…[et al.]. Yangyin Runchang Decoction Improves Intestinal Motility in Mice with AtropineDiphenoxylate-Induced Slow-Transit Constipation. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153699