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Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis
المؤلفون المشاركون
Knani, Ines
Bouzidi, Hsan
Kerkeni, Mohsen
Zrour, Saoussen
Bergaoui, Naceur
Hammami, Mohamed
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The contribution of methylglyoxal (MGO) and soluble receptor for advanced glycation end products (sRAGE) in the presence of rheumatoid arthritis (RA) is still unknown.
We investigated whether serum MGO and sRAGE were related to the presence of disease activity in RA.
Methods.
80 patients with RA and 30 control subjects were included in a cross-sectional study.
The severity of RA was assessed using the disease activity score for 28 joints (DAS28).
Serum MGO and sRAGE were measured by ELISA.
Results.
Serum MGO levels were significantly higher in patients with RA versus control subjects (P<0.001) and were increased in RA patients with higher disease activity versus RA patients with moderate disease activity (P=0.019).
Serum sRAGE concentrations were significantly decreased in RA patients with higher disease activity versus RA patients with moderate disease activity and versus control subjects (P=0.004; P=0.002, resp.).
A multiple logistic regression analysis demonstrated that MGO was independently associated with the presence of activity disease in RA (OR = 1.17, 95% CI: 1.02–1.31, P=0.01).
Conclusion.
Serum MGO and sRAGE levels are inversely related to the activity of RA, and MGO is independently associated with a higher disease activity of RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Knani, Ines& Bouzidi, Hsan& Zrour, Saoussen& Bergaoui, Naceur& Hammami, Mohamed& Kerkeni, Mohsen. 2018. Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis. Disease Markers،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153726
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Knani, Ines…[et al.]. Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis. Disease Markers No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1153726
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Knani, Ines& Bouzidi, Hsan& Zrour, Saoussen& Bergaoui, Naceur& Hammami, Mohamed& Kerkeni, Mohsen. Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153726
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153726
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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