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Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis
Joint Authors
Knani, Ines
Bouzidi, Hsan
Kerkeni, Mohsen
Zrour, Saoussen
Bergaoui, Naceur
Hammami, Mohamed
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The contribution of methylglyoxal (MGO) and soluble receptor for advanced glycation end products (sRAGE) in the presence of rheumatoid arthritis (RA) is still unknown.
We investigated whether serum MGO and sRAGE were related to the presence of disease activity in RA.
Methods.
80 patients with RA and 30 control subjects were included in a cross-sectional study.
The severity of RA was assessed using the disease activity score for 28 joints (DAS28).
Serum MGO and sRAGE were measured by ELISA.
Results.
Serum MGO levels were significantly higher in patients with RA versus control subjects (P<0.001) and were increased in RA patients with higher disease activity versus RA patients with moderate disease activity (P=0.019).
Serum sRAGE concentrations were significantly decreased in RA patients with higher disease activity versus RA patients with moderate disease activity and versus control subjects (P=0.004; P=0.002, resp.).
A multiple logistic regression analysis demonstrated that MGO was independently associated with the presence of activity disease in RA (OR = 1.17, 95% CI: 1.02–1.31, P=0.01).
Conclusion.
Serum MGO and sRAGE levels are inversely related to the activity of RA, and MGO is independently associated with a higher disease activity of RA.
American Psychological Association (APA)
Knani, Ines& Bouzidi, Hsan& Zrour, Saoussen& Bergaoui, Naceur& Hammami, Mohamed& Kerkeni, Mohsen. 2018. Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis. Disease Markers،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153726
Modern Language Association (MLA)
Knani, Ines…[et al.]. Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis. Disease Markers No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1153726
American Medical Association (AMA)
Knani, Ines& Bouzidi, Hsan& Zrour, Saoussen& Bergaoui, Naceur& Hammami, Mohamed& Kerkeni, Mohsen. Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153726