Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women
المؤلفون المشاركون
Mohammed, Abdul Khader
Bukhari, Ihtisham
Hussain, Syed Danish
Abdi, Saba
Ansari, Mohammed G. A.
BinBaz, Rawan A.
Aljohani, Naji
Al-Daghri, Nasser M.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The RANKL/RANK/OPG pathway regulates bone remodelling and turnover.
However, the genetic background of bone mineral density (BMD) and osteopenia in Saudi postmenopausal women is yet to be studied.
We studied the genetic polymorphism of RANKL/RANK/OPG with BMD and other associated factors in Saudi postmenopausal osteopenic women.
A total of 439 (223 osteopenia and 216 control) postmenopausal women were recruited from the orthopaedic department of the King Khalid University Hospital, Riyadh, KSA.
Genetic variants of RANK (rs1805034 and rs35211496), RANKL (rs2277438 and rs9533156), and OPG (rs2073618 and rs3102735) were genotyped using RT-PCR.
Anthropometrics, bone mineral density, and other bone markers were measured.
The levels of bone turnover markers, PTH, and RANKL were found to be significantly different between control and the osteopenia group.
The odds ratio of 2.37 (1.00–5.69) for RANK SNP (rs1805034) indicates that subjects with CC genotype are more vulnerable to developing osteopenia as compared to subjects with TT genotype.
Similarly, for RANKL SNP (rs2277438), the significant odds ratio of 20.56 (9.82–43.06) indicates that the subjects with GG genotype are at significantly higher risk of having osteopenia compared with the AA genotype subjects.
In addition, G allele in rs2277438 also found to be a risk factor for osteopenia 4.54 (3.18–6.49) compared with A allele.
However, none of the OPG genotypes shows association with osteopenia.
The association of RANK polymorphisms with osteopenia shows its clinical importance in the diagnosis and prognosis of the bone diseases; here, we suggest that the subjects with RANK and RANKL polymorphisms may develop osteoporosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdi, Saba& Bukhari, Ihtisham& Ansari, Mohammed G. A.& BinBaz, Rawan A.& Mohammed, Abdul Khader& Hussain, Syed Danish…[et al.]. 2020. Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women. Disease Markers،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1153751
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdi, Saba…[et al.]. Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women. Disease Markers No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1153751
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdi, Saba& Bukhari, Ihtisham& Ansari, Mohammed G. A.& BinBaz, Rawan A.& Mohammed, Abdul Khader& Hussain, Syed Danish…[et al.]. Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1153751
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153751
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر