Study of Guanxinning Injection on Regulatory Mechanism of Bcl-2 and Bax by Liquid Nitrogen Freezing-Mediated Femoral Head Necrosis
المؤلفون المشاركون
Xu, Xilin
Zhang, Xiaofeng
Lv, Hang
Li, Xiaodong
Zhang, Jie
Su, Hui
Liu, Peiran
Hu, Hai
Litscher, Daniela
Wang, Lu
Litscher, Gerhard
Sheng, Zemin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The objective of this study was to investigate the impact of femoral head perfusion by traditional Chinese medicine Guanxinning injection promoting blood circulation for removing blood stasis on the expression of Bcl-2 and Bax induced by liquid nitrogen freezing-mediated femoral head necrosis.
90 rabbits were randomized into three groups.
Normal control group was not subjected to any medication.
Saline and Guanxinning group were perfused with 0.9% saline and Guanxinning injection once every three days through the hip joint, respectively.
Six animals in each group were sacrificed at weeks 1, 3, 6, 9, and 12.
PCR and Western blot measured the expressions of Bcl-2 and Bax in the femoral head.
The bax expression in the Guanxinning group reduced at the third week significantly compared to the normal control group (P<0.01).
The Bcl-2 expression in the Guanxinning group increased substantially at the third week (P<0.05 or P<0.01).
Prolonged treatment elevated the expression of Bcl-2 in the Guanxinning group while that of Bax reduced remarkably (P<0.01).
Moreover, the ratio of Bcl-2 to Bax increased gradually in the Guanxinning group with prolonged drug administration.
Guanxinning injection can inhibit the cell apoptosis of femoral head necrosis through the treatment by femoral head perfusion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Xiaofeng& Xu, Xilin& Litscher, Gerhard& Sheng, Zemin& Wang, Lu& Litscher, Daniela…[et al.]. 2017. Study of Guanxinning Injection on Regulatory Mechanism of Bcl-2 and Bax by Liquid Nitrogen Freezing-Mediated Femoral Head Necrosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153788
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Xiaofeng…[et al.]. Study of Guanxinning Injection on Regulatory Mechanism of Bcl-2 and Bax by Liquid Nitrogen Freezing-Mediated Femoral Head Necrosis. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153788
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Xiaofeng& Xu, Xilin& Litscher, Gerhard& Sheng, Zemin& Wang, Lu& Litscher, Daniela…[et al.]. Study of Guanxinning Injection on Regulatory Mechanism of Bcl-2 and Bax by Liquid Nitrogen Freezing-Mediated Femoral Head Necrosis. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153788
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153788
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر