Cytokines and Chemokines Are Detectable in Swivel-Derived Exhaled Breath Condensate (SEBC): A Pilot Study in Mechanically Ventilated Patients
المؤلفون المشاركون
van der Zee, Philip
van Walree, Inez
Fijen, Jan-Willem
van Houte, Arend-Jan
van Velzen-Blad, Heleen
Rijkers, Ger
Gommers, Diederik
Endeman, Henrik
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Exhaled breath condensate (EBC) is a noninvasive method to collect samples from the respiratory tract.
Usually, a thermoelectric cooling module is required to collect sufficient EBC volume for analyses.
In here, we assessed the feasibility of cytokine and chemokine detection in EBC collected directly from the ventilator circuit without the use of a cooling module: swivel-derived exhaled breath condensate (SEBC).
Methods.
SEBC was prospectively collected from the swivel adapter and stored at -80°C.
The objective of this study was to detect cytokines and chemokines in SEBC with a multiplex immunoassay.
Secondary outcomes were to assess the correlation between cytokine and chemokine concentrations in SEBC and mechanical ventilation parameters, systemic inflammation parameters, and hemodynamic parameters.
Results.
Twenty-nine SEBC samples were obtained from 13 ICU patients.
IL-1β, IL-4, IL-8, and IL-17 were detected in more than 90% of SEBC samples, and significant correlations between multiple cytokines and chemokines were found.
Several significant correlations were found between cytokines and chemokines in SEBC and mechanical ventilation parameters and serum lactate concentrations.
Conclusion.
This pilot study showed that it is feasible to detect cytokines and chemokines in SEBC samples obtained without a cooling module.
Despite small sample size, correlations were found between cytokines and chemokines in SEBC and mechanical ventilation parameters, as well as serum lactate concentrations.
This simple SEBC collection method provides the opportunity to collect EBC samples in large prospective ICU cohorts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
van der Zee, Philip& van Walree, Inez& Fijen, Jan-Willem& van Houte, Arend-Jan& van Velzen-Blad, Heleen& Rijkers, Ger…[et al.]. 2020. Cytokines and Chemokines Are Detectable in Swivel-Derived Exhaled Breath Condensate (SEBC): A Pilot Study in Mechanically Ventilated Patients. Disease Markers،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1153803
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
van der Zee, Philip…[et al.]. Cytokines and Chemokines Are Detectable in Swivel-Derived Exhaled Breath Condensate (SEBC): A Pilot Study in Mechanically Ventilated Patients. Disease Markers No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1153803
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
van der Zee, Philip& van Walree, Inez& Fijen, Jan-Willem& van Houte, Arend-Jan& van Velzen-Blad, Heleen& Rijkers, Ger…[et al.]. Cytokines and Chemokines Are Detectable in Swivel-Derived Exhaled Breath Condensate (SEBC): A Pilot Study in Mechanically Ventilated Patients. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1153803
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153803
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر